N-Methyl-3,4-methylenedioxyamphetamine-induced hepatotoxicity in rats: Oxidative stress after acute and chronic administration [PDF]
Vojnosanitetski Pregled, 2004 Background. The underlying mechanisms of N-Methyl-3,4-methylenedioxyamphetamine-MDMA-induced hepatotoxicity are still unknown. The aim of this study was to evaluate hepatic oxido-reductive status in the rats liver after the single and repeated ...
Ninković Milica +4 more
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From Efficacy to Effectiveness: Evaluating Psychedelic Randomized Controlled Trials for Trustworthy Evidence‐Based Policy and Practice [PDF]
Pharmacology Research & PerspectivesThe recent review of a new drug application for MDMA‐assisted therapy for posttraumatic stress disorder by the United States' Food and Drug Administration (FDA) highlighted epistemological and methodological challenges for evidence assessments.
Eduardo Ekman Schenberg
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MDMA (N-methyl-3,4-methylenedioxyamphetamine) and its stereoisomers: Similarities and differences in behavioral effects in an automated activity apparatus in mice [PDF]
Pharmacology Biochemistry and Behavior, 2008 Racemic MDMA (0.3-30 mg/kg), S(+)-MDMA (0.3-30 mg/kg), R(-)-MDMA (0.3-50 mg/kg) and saline vehicle (10 ml/kg) were comprehensively evaluated in fully automated and computer-integrated activity chambers, which were designed for mice, and provided a detailed analysis of the frequency, location, and/or duration of 18 different activities.
Richard, Young, Richard A, Glennon
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The Effects of Folic Acid on Testicular Histology, Sperm Quality, and Spermatogenesis Indices Following 3,4-Methylenedioxymethamphetamine Exposure in Adult Male Rats [PDF]
Addiction and Health, 2021 Background: There is an increasing concern over acute exposure of amphetamine and its derivative such as3,4-methylenedioxymethamphetamine (MDMA) on male reproductive toxicity. Supplementary vitamins canreduce the oxidative stresses and repair the damages
Iman Rad +6 more
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Trends in toxicological findings and drug seizures of MDMA in New Zealand from 2010 to 2022. [PDF]
J Forensic SciAbstract 3,4‐Methylenedioxymethamphetamine (MDMA) or “ecstasy,” is a commonly used drug worldwide, including in New Zealand, where 4.8% of the population aged 15 years or over reported using it in a 2023/2024 survey. This study provides additional insights on MDMA prevalence data in New Zealand by reporting toxicology data from Coronial and driving ...
Sheehan TJ +4 more
europepmc +2 more sources
Entactogens: How the Name for a Novel Class of Psychoactive Agents Originated
Frontiers in Psychiatry, 2022 At first glance, it appears there is little difference between the molecular structures of methylenedioxymethamphetamine (MDMA), which has an N-methyl attached to its amino group, and methylenedioxyamphetamine (MDA), a primary amine that is recognized to
David E. Nichols
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Ecstasy tablets intoxication with lethal autcome [PDF]
Vojnosanitetski Pregled, 2007 Background. Ecstasy, 3,4-methylenedioxymethamphetamine (MDMA), is a synthetic compound increasingly popular as a recreational drug. Tablets known as ecstasy contain MDMA, but may also contain caffeine, ephedrine, paramethoxyamphetamine, 3,4 ...
Đorđević Snežana +1 more
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Impact of cytochrome P450 2D6 function on the chiral blood plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its phase I and II metabolites in humans [PDF]
, 2016 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) metabolism is known to be stereoselective, with preference for S-stereoisomers. Its major metabolic step involves CYP2D6-catalyzed demethylenation to 3,4-dihydroxymethamphetamine (DHMA), followed by ...
Tingelhoff, Eva H. +26 more
core +1 more source
Polyacrylonitrile Nanofiber-Based Quartz Crystal Microbalance for Sensitive Detection of Safrole
Sensors, 2018 Safrole is the main precursor for producing the amphetamine-type stimulant (ATS) drug, N-methyl-3,4-methylenedioxyamphetamine (MDMA), also known as ecstasy.
Aditya Rianjanu +6 more
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Recurrent Syncope following Substance Abuse; a Case Report
Emergency, 2016 Drug abuse is considered as the most common poisoning in the world. Stimulants agent especially amphetamines and methamphetamines are among important abused substances.
Forod Salehi +3 more
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