Results 21 to 30 of about 10,867,794 (139)
Drug Testing and Analysis, Volume 17, Issue 10, Page 1877-1895, October 2025.This study is related to the development of a microextraction method for the determination of 56 psychoactive substances in oral fluid. Sample clean‐up is obtained by parallel artificial liquid membrane extraction and analyzed by liquid chromatography–tandem mass spectrometry.
Martina Croce +6 more
wiley +1 more source
N-Substituted 9β-Methyl-5-(3-hydroxyphenyl)morphans Are Opioid Receptor Pure Antagonists
, 2016 The inhibition of radioligand binding and [35S]GTPγS functional assay data for N-methyl- and N-phenethyl-9β-methyl-5-(3-hydroxyphenyl)morphans (5b and 5c) show that these compounds are pure antagonists at the μ, δ, and κ opioid receptors. Since 5b and 5c
James B. Thomas (1324521) +10 more
core +1 more source
Fayixue ZazhiObjectiveTo explore the mechanism of myocardial toxicity caused by N-methyl-3,4-methyle-nedioxyamphetamine （MDMA）, the changes of intracellular calcium oscillation mode and calcium handling proteins during acute exposure to different concentrations of ...
WANG Rong-shuai +8 more
doaj +1 more source
Analytical Science Advances, Volume 6, Issue 1, June 2025.ABSTRACT Liquid chromatography–mass spectrometry (LC–MS) is a highly sophisticated analytical technique that has become indispensable for sample analysis across various scientific domains. In recent years, LC–MS has emerged as a cornerstone technology in comparative replicate sample analysis, particularly in the fields of proteomics, lipidomics and ...
Samyah Alanazi
wiley +1 more source
Rapid Analytical Method for Quantification of Gamma‐Hydroxybutyrate (GHB) in Hair by UPLC‐MS/MS
Drug Testing and Analysis, Volume 17, Issue 6, Page 903-914, June 2025.A rapid and simple UPLC‐MS/MS method for quantification of GHB in 10 mg of hair was developed. The method was satisfactorily validated, showing a linear range of 0.5–50 ng/mg, which allows us to quantify endogenous and exogenous GHB concentrations.
Miriam Blanco‐Ces +5 more
wiley +1 more source
Advanced Science, Volume 12, Issue 17, May 8, 2025.This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li +3 more
wiley +1 more source
N′-Acetyl-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide
, 2020 Synthesis of N′-acetyl-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide from the phenyl acetates of 3-acetyl-5-(3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-yl)-2,3-dihydro-1,3,4-oxadiazol-2-yl in alkaline medium and its ...
Luiza R. S. Dias, Júlio C. A. V. Soares
core +1 more source
Advanced Science, Volume 12, Issue 15, April 17, 2025.Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim +5 more
wiley +1 more source
Density Functional Theory in Forensic Science: Applications and Challenges
WIREs Forensic Science, Volume 7, Issue 1, March 2025.DFT and other in silico methods are increasingly applied in forensic analysis. This review highlights the use of DFT in key areas such as new psychoactive substances, food adulteration, blood analysis, latent fingerprint detection, and explosives.
Lívia Salviano Mariotto +4 more
wiley +1 more source
Accumulation of neurotoxic thioether metabolites of 3,4-(±)-methylenedioxymethamphetamine in rat [PDF]
, 2008 The serotonergic neurotoxicity of 3,4-(Ϯ)-methylenedioxymethamphetamine (MDMA) appears dependent upon systemic metabolism because direct injection of MDMA into the brain fails to reproduce the neurotoxicity.
Serrine S Lau +2 more
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