Results 21 to 30 of about 1,268 (94)

Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim, Sumin Yang, Jeehye Jung, Jeonghyeon Choi, Mingon Kang, Jae‐Yeol Joo   +5 more
wiley   +1 more source

Density Functional Theory in Forensic Science: Applications and Challenges

WIREs Forensic Science, Volume 7, Issue 1, March 2025.
DFT and other in silico methods are increasingly applied in forensic analysis. This review highlights the use of DFT in key areas such as new psychoactive substances, food adulteration, blood analysis, latent fingerprint detection, and explosives.
Lívia Salviano Mariotto, Caio Henrique Pinke Rodrigues, Nigel John Mason, Aline Thaís Bruni, Felipe Fantuzzi   +4 more
wiley   +1 more source

Sex differences in the effects of N‐ethylpentylone in young CD1 mice: Insights on behaviour, thermoregulation and early gene expression

British Journal of Pharmacology, Volume 181, Issue 22, Page 4491-4513, November 2024.
Abstract Background and Purpose New psychoactive substances such as N‐ethylpentylone (NEP) are continuously emerging in the illicit drug market, and knowledge of their effects and risks, which may vary between sexes, is scarce. Our present study compares some key effects of NEP in male and female mice.
María Espinosa‐Velasco, Adriana Castro‐Zavala, Marina D. Reguilón, Inés Gallego‐Landin, Marina Bellot, Olga Rublinetska, Olga Valverde, Marta Rodríguez‐Arias, Núria Nadal‐Gratacós, Xavier Berzosa, Cristian Gómez‐Canela, Marcel·lí Carbó, Jorge Camarasa, Elena Escubedo, Raúl López‐Arnau, David Pubill   +15 more
wiley   +1 more source

Novel harm reduction measures at music festivals in Australia: Pilot implementation of the Emerging Drugs Network of Australia–Victoria toxicosurveillance methodology

Drug and Alcohol Review, Volume 43, Issue 7, Page 2045-2054, November 2024.
Abstract Introduction Harm reduction strategies at music festivals seek to create a safer environment for patrons. The Emerging Drugs Network of Australia–Victoria (EDNAV) project is a state‐wide toxicosurveillance network that derives drug intelligence from a sample of patients presenting to hospital with illicit drug‐related toxicity.
Rebekka Syrjanen, Martin Dutch, Shaun L. Greene, Tom Lyons, Ginny McKinnon, Dimitri Gerostamoulos, Jennifer L. Schumann, on behalf of the EDNAV Project Research Group   +7 more
wiley   +1 more source

Comparison of the Effects of Ecstasy and Methamphetamine on the RB1 Mouse Embryonic Stem Cells Differentiation into Neural Cells

مجله دانشکده پزشکی اصفهان, 2013
Background: N-Methyl-3,4-Methylenedioxymethamphetamine (MDMA) and methamphetamine (MA) from the amphetamine family, which are respectively known as ecstasy and ice, have well-established neurotoxic effects on the serotonergic and dopaminergic systems ...
Leila Dehghani, Rokhsareh Meamar
doaj  

Quantitative analysis of tetrahydrocannabinol isomers and other toxicologically relevant drugs in blood

Drug Testing and Analysis, Volume 16, Issue 10, Page 1102-1112, October 2024.
Isomers of tetrahydrocannabinol (THC) may complicate valid and defensible confirmatory analysis in forensic toxicology. This article presents a multi‐analyte liquid chromatography‐tandem mass spectrometry method involving the separation of THC isomers in addition to other commonly encountered drugs and metabolites.
Dylan Mantinieks, Matthew Di Rago, Olaf H. Drummer, Linda Glowacki, Jennifer Schumann, Dimitri Gerostamoulos   +5 more
wiley   +1 more source

Trends in toxicological findings in unintentional opioid or stimulant toxicity deaths in Québec, Canada, 2012–2021: Has Québec entered a new era of drug‐related deaths?

Drug and Alcohol Review, Volume 43, Issue 6, Page 1613-1624, September 2024.
Abstract Introduction We aimed to describe rates and toxicological findings of unintentional opioid and stimulant toxicity deaths, 2012–2021. Methods The dataset included accidental deaths determined by the Coroner to be due to opioids or stimulants.
Uyen Do, Paul‐André Perron, Julie Bruneau, Sarah Larney   +3 more
wiley   +1 more source

Bioisosteric analogs of MDMA: Improving the pharmacological profile?

Journal of Neurochemistry, Volume 168, Issue 9, Page 2022-2042, September 2024.
This study explores three new bioisosteric replacements of the methylenedioxy group of MDMA, resulting in ODMA, TDMA, and SeDMA. Compared to MDMA, these bioisosteres have shown an alternative hepatic metabolism, with different resulting metabolites and an improved metabolic stability for TDMA.
Ana Sofia Alberto‐Silva, Selina Hemmer, Hailey A. Bock, Leticia Alves da Silva, Kenneth R. Scott, Nina Kastner, Manan Bhatt, Marco Niello, Kathrin Jäntsch, Oliver Kudlacek, Elena Bossi, Thomas Stockner, Markus R. Meyer, John D. McCorvy, Simon D. Brandt, Pierce Kavanagh, Harald H. Sitte   +16 more
wiley   +1 more source

Psychedelic therapy in depression and substance use disorders

European Journal of Neuroscience, Volume 60, Issue 2, Page 4063-4077, July 2024.
Psychedelics changes in perception through serotonin receptor agonism. Effects on the 5HT2A receptor; neuroplasticity and transcriptomic regulation, as well as specific changes in neural correlates of brain networks. Psychedelic‐assisted therapy in disorders such as depression, anxiety and substance use disorders constitutes a strong research area ...
Nur Damla Korkmaz, Ugur Cikrikcili, Merve Akan, Emrah Yucesan   +3 more
wiley   +1 more source

Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease

Advanced Therapeutics, Volume 7, Issue 5, May 2024.
Black phosphorus microbubbles (BP@MBs) combined with focused ultrasound to open the blood‐brain barrier for treatment of Parkinson's disease (PD) is constructed. BP@MBs have antioxidant effects, reduce neuronal apoptosis and improve motor symptoms of PD in vitro and in vivo.
Shuyuan Guo, Zhuxia Zhang, Bingxuan Xu, Mengxin Wang, Taojian Fan, Xinliang Zhong, Azhen Hu, Die Hu, Lan Luo, Shuping Lin, Linlin Wang, Rongquan Yao, Jiabao Huang, Huiying Hu, Xintao Shuai, Jie Shi, Yun Chen, Tingting Zheng   +17 more
wiley   +1 more source