Results 41 to 50 of about 10,867,794 (139)

2-Fluoro-N-methyl-N-{[(3S*,4S*)-4-(2-methylphenoxy)-3,4-dihydro-1H-isochromen-3-yl]methyl}ethanamine

, 2015
Starting from N-methyl-1-[(3S*,4S*)-4-(2-methylphenoxy)-3,4-dihydro-1H-isochromen-3-yl]methanamine (1) target compound 2 is prepared in a mild, direct alkylation approach with 2-fluoroethyl ...
Christina Rami-Mark, Karem Shanab, Markus Mitterhauser, Helmut Spreitzer, Catharina Neudorfer, Wolfgang Holzer, Wolfgang Wadsak   +6 more
core   +2 more sources

Trends in toxicological findings in unintentional opioid or stimulant toxicity deaths in Québec, Canada, 2012–2021: Has Québec entered a new era of drug‐related deaths?

Drug and Alcohol Review, Volume 43, Issue 6, Page 1613-1624, September 2024.
Abstract Introduction We aimed to describe rates and toxicological findings of unintentional opioid and stimulant toxicity deaths, 2012–2021. Methods The dataset included accidental deaths determined by the Coroner to be due to opioids or stimulants.
Uyen Do, Paul‐André Perron, Julie Bruneau, Sarah Larney   +3 more
wiley   +1 more source

Bioisosteric analogs of MDMA: Improving the pharmacological profile?

Journal of Neurochemistry, Volume 168, Issue 9, Page 2022-2042, September 2024.
This study explores three new bioisosteric replacements of the methylenedioxy group of MDMA, resulting in ODMA, TDMA, and SeDMA. Compared to MDMA, these bioisosteres have shown an alternative hepatic metabolism, with different resulting metabolites and an improved metabolic stability for TDMA.
Ana Sofia Alberto‐Silva, Selina Hemmer, Hailey A. Bock, Leticia Alves da Silva, Kenneth R. Scott, Nina Kastner, Manan Bhatt, Marco Niello, Kathrin Jäntsch, Oliver Kudlacek, Elena Bossi, Thomas Stockner, Markus R. Meyer, John D. McCorvy, Simon D. Brandt, Pierce Kavanagh, Harald H. Sitte   +16 more
wiley   +1 more source

(+/-)3,4-Methylenedioxyamphetamine Elicits Action Potential Bursts in a Central Snail Neuron

, 2008
The effects of (+/-)3,4-methylenedioxyamphetamine (MDA) were studied in an identifiable RP4 neuron of the African snail, Achatina.fulica Ferussac, using the two-electrode voltage- clamp method.
蔡明正;陳易宏, TSAI, MING-CHENG;CHEN, YI-HUNG   +1 more
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Methyl 1-n-butyl-2-(3,4-dichlorophenyl)-1H-benzimidazole-5-carboxylate

, 2004
A new benz­imidazole compound, methyl 1-n-butyl-2-(3,4-di­chloro­phenyl)-1H-benz­imidazole-5-carboxyl­ate, C19H18Cl2N2O2, has been synthesized by the condensation of methyl 3-amino-4-(n-butyl­amino)­benzoate with an Na2S2O5 adduct of 3,4-di­chloro­benz ...
Karataş, Hacer, Özden, Seçkin
core   +1 more source

Psychedelic therapy in depression and substance use disorders

European Journal of Neuroscience, Volume 60, Issue 2, Page 4063-4077, July 2024.
Psychedelics changes in perception through serotonin receptor agonism. Effects on the 5HT2A receptor; neuroplasticity and transcriptomic regulation, as well as specific changes in neural correlates of brain networks. Psychedelic‐assisted therapy in disorders such as depression, anxiety and substance use disorders constitutes a strong research area ...
Nur Damla Korkmaz, Ugur Cikrikcili, Merve Akan, Emrah Yucesan   +3 more
wiley   +1 more source

Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease

Advanced Therapeutics, Volume 7, Issue 5, May 2024.
Black phosphorus microbubbles (BP@MBs) combined with focused ultrasound to open the blood‐brain barrier for treatment of Parkinson's disease (PD) is constructed. BP@MBs have antioxidant effects, reduce neuronal apoptosis and improve motor symptoms of PD in vitro and in vivo.
Shuyuan Guo, Zhuxia Zhang, Bingxuan Xu, Mengxin Wang, Taojian Fan, Xinliang Zhong, Azhen Hu, Die Hu, Lan Luo, Shuping Lin, Linlin Wang, Rongquan Yao, Jiabao Huang, Huiying Hu, Xintao Shuai, Jie Shi, Yun Chen, Tingting Zheng   +17 more
wiley   +1 more source

Thermochemical Properties of 4-N,N-Dialkylamino-7-Nitrobenzofurazan Derivatives (Alkyl = Methyl, Ethyl) [PDF]

, 2014
Article discussing the thermochemical properties of 4-N,N-dialkylamino-7-nitrobenzofurazan derivatives (alkyl = methyl, ethyl)
Silva, Ana L. R., Gonçalves, Jorge M., Santiago, Otília D. F., Pandey, Siddharth, Santos, Ana Filipa Lima Osório de Magalhães, Silva, Maria D. M. C. Ribeiro da, Acree, William E. (William Eugene)   +6 more
core   +1 more source

Isotope ratio analysis of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethylamphetamine (MDMA) synthesised from helional

, 2022
Illicit drug profiling describes the applications of chemical or physical drug profiles to areas such as law enforcement and legislation. Stable isotope analysis by stable isotope ratio mass spectrometry (IRMS) has become a useful tool for illicit drug ...
Cormick, Justin
core   +1 more source

Clandestine Manufacture of 3,4-Methylenedioxyamphetamine (MDA) From Helional via α-Methyl-3,4-methylenedioxyphenylpropionitrile (MMDPPN)

, 2019
There appears to be an endless quest to circumvent existing legislation in the clandestine manufacture of dangerous drugs. One such pathway encountered in recent years is the conversion of unrestricted helional into 3,4-methylenedioxyamphetamine (MDA) by
Davis, Sean, Cotton, Marcus, Currie, Timothy, Boyd, Sue   +3 more
core