Results 41 to 50 of about 13,980,406 (134)

Comparison of the Effects of Ecstasy and Methamphetamine on the RB1 Mouse Embryonic Stem Cells Differentiation into Neural Cells

مجله دانشکده پزشکی اصفهان, 2013
Background: N-Methyl-3,4-Methylenedioxymethamphetamine (MDMA) and methamphetamine (MA) from the amphetamine family, which are respectively known as ecstasy and ice, have well-established neurotoxic effects on the serotonergic and dopaminergic systems ...
Leila Dehghani, Rokhsareh Meamar
doaj  

Sex differences in the effects of N‐ethylpentylone in young CD1 mice: Insights on behaviour, thermoregulation and early gene expression

British Journal of Pharmacology, Volume 181, Issue 22, Page 4491-4513, November 2024.
Abstract Background and Purpose New psychoactive substances such as N‐ethylpentylone (NEP) are continuously emerging in the illicit drug market, and knowledge of their effects and risks, which may vary between sexes, is scarce. Our present study compares some key effects of NEP in male and female mice.
María Espinosa‐Velasco, Adriana Castro‐Zavala, Marina D. Reguilón, Inés Gallego‐Landin, Marina Bellot, Olga Rublinetska, Olga Valverde, Marta Rodríguez‐Arias, Núria Nadal‐Gratacós, Xavier Berzosa, Cristian Gómez‐Canela, Marcel·lí Carbó, Jorge Camarasa, Elena Escubedo, Raúl López‐Arnau, David Pubill   +15 more
wiley   +1 more source

Novel harm reduction measures at music festivals in Australia: Pilot implementation of the Emerging Drugs Network of Australia–Victoria toxicosurveillance methodology

Drug and Alcohol Review, Volume 43, Issue 7, Page 2045-2054, November 2024.
Abstract Introduction Harm reduction strategies at music festivals seek to create a safer environment for patrons. The Emerging Drugs Network of Australia–Victoria (EDNAV) project is a state‐wide toxicosurveillance network that derives drug intelligence from a sample of patients presenting to hospital with illicit drug‐related toxicity.
Rebekka Syrjanen, Martin Dutch, Shaun L. Greene, Tom Lyons, Ginny McKinnon, Dimitri Gerostamoulos, Jennifer L. Schumann, on behalf of the EDNAV Project Research Group   +7 more
wiley   +1 more source

Synthesis of Novel N-Acylhydrazones and Their C-N/N-N Bond Conformational Characterization by NMR Spectroscopy

, 2021
In this article, a synthesis of N’-(benzylidene)-2-(6-methyl-1H-pyrazolo[3,4-b]quinolin-1-yl)acetohydrazides and their structural interpretation by NMR experiments is described in an attempt to explain the duplication of some peaks in their 1H- and 13C ...
Rubina Munir, Rahila Huma, Ayesha Roohi, Muhammad Makshoof Athar, Noman Javid, Muhammad Zia-ur-Rehman, Muhammad Zaheer   +6 more
core   +1 more source

Anhydrous versus hydrated N-4-substituted 1H-pyrazolo[3,4-d]pyrimidine-4,6-diamines: hydrogen bonding in two and three dimensions

, 2008
Ten new N-4-substituted 1H-pyrazolo[3,4-d]pyrimidine-4,6-diamines have been synthesized and the structures of nine of them are reported here, falling into two clear groups, those which are stoichiometric hydrates and those which crystallize in solvent ...
Marchal, Antonio, Trilleras, Jorge, Cobo, Justo, Low, John N., Nogueras, Manuel, Quiroga, Jairo, Glidewell, Christopher   +6 more
core   +2 more sources

Quantitative analysis of tetrahydrocannabinol isomers and other toxicologically relevant drugs in blood

Drug Testing and Analysis, Volume 16, Issue 10, Page 1102-1112, October 2024.
Isomers of tetrahydrocannabinol (THC) may complicate valid and defensible confirmatory analysis in forensic toxicology. This article presents a multi‐analyte liquid chromatography‐tandem mass spectrometry method involving the separation of THC isomers in addition to other commonly encountered drugs and metabolites.
Dylan Mantinieks, Matthew Di Rago, Olaf H. Drummer, Linda Glowacki, Jennifer Schumann, Dimitri Gerostamoulos   +5 more
wiley   +1 more source

(+/-)3,4-Methylenedioxyamphetamine Elicits Action Potential Bursts in a Central Snail Neuron

, 2008
The effects of (+/-)3,4-methylenedioxyamphetamine (MDA) were studied in an identifiable RP4 neuron of the African snail, Achatina.fulica Ferussac, using the two-electrode voltage- clamp method.
蔡明正;陳易宏, TSAI, MING-CHENG;CHEN, YI-HUNG   +1 more
core  

4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

, 2021
A novel 4-chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine was prepared by a rational and short two-step synthesis from commercially available ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate via 6-(chloromethyl)-1-methyl-1,5-dihydro-4H ...
Oleg A. Rakitin, Oleg Rakitin, Vladimir Ogurtsov, Vladimir A. Ogurtsov   +3 more
core   +1 more source

Trends in toxicological findings in unintentional opioid or stimulant toxicity deaths in Québec, Canada, 2012–2021: Has Québec entered a new era of drug‐related deaths?

Drug and Alcohol Review, Volume 43, Issue 6, Page 1613-1624, September 2024.
Abstract Introduction We aimed to describe rates and toxicological findings of unintentional opioid and stimulant toxicity deaths, 2012–2021. Methods The dataset included accidental deaths determined by the Coroner to be due to opioids or stimulants.
Uyen Do, Paul‐André Perron, Julie Bruneau, Sarah Larney   +3 more
wiley   +1 more source

Clandestine Manufacture of 3,4-Methylenedioxyamphetamine (MDA) From Helional via α-Methyl-3,4-methylenedioxyphenylpropionitrile (MMDPPN)

, 2019
There appears to be an endless quest to circumvent existing legislation in the clandestine manufacture of dangerous drugs. One such pathway encountered in recent years is the conversion of unrestricted helional into 3,4-methylenedioxyamphetamine (MDA) by
Davis, Sean, Cotton, Marcus, Currie, Timothy, Boyd, Sue   +3 more
core