Results 51 to 60 of about 13,980,406 (134)

Synthesis of 4-methyl-2H-1,2,3-benzothiadiazine 1,1-dioxides and their further transformation via alkylation and reduction steps

, 2019
Ortho lithiation of acetophenone ketals followed by introduction of the chlorosulphonyl group and subsequent ring closure with hydrazine monohydrate or acetohydrazide gave rise to the formation of variously substituted 4-methyl-1,2,3-benzothiadiazine 1,1-
Gyöngyvér Pusztai (7494908), Zsófia Garádi (7494911), Gyula Simig (2160061), Balázs Volk (2441869), Gábor Tóth (5942), Márta Porcs-Makkay (2491447), Imre Gyűjtő (7494902), Bálint Nyulasi (7494914), Gyula Lukács (7494905)   +8 more
core   +1 more source

N-Substituted 9β-Methyl-5-(3-hydroxyphenyl)morphans Are Opioid Receptor Pure Antagonists

, 2016
The inhibition of radioligand binding and [35S]GTPγS functional assay data for N-methyl- and N-phenethyl-9β-methyl-5-(3-hydroxyphenyl)morphans (5b and 5c) show that these compounds are pure antagonists at the μ, δ, and κ opioid receptors. Since 5b and 5c
James B. Thomas (1324521), Richard B. Rothman (354207), S. Wayne Mascarella (1307766), Buddy E. Cantrell (2725051), Xiaoling Zheng (3022464), Judith L. Flippen-Anderson (5752), Clifford F. George (2952312), John S. Partilla (1322421), Dennis M. Zimmerman (2725048), F. Ivy Carroll (445446), Christina M. Dersch (354210)   +10 more
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Organic impurity profiling of 3,4-methylenedioxyamphetamine (MDA) synthesised from helional. [PDF]

The organic impurity profile of 3,4-methylenedioxyamphetamine (MDA) synthesised from helional via the "twodogs" method was examined to identify route-specific and condition-specific impurities.
Mercieca, AL, Fursman, HC, Chadwick, S, Alonzo, M, McDonagh, AM   +4 more
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Reduced 3,4′-bi­pyrazoles carrying thio­phene and thia­zole substituents: structures of two intermediates and two products

, 2021
Cyclo­addition reactions between 3-(5-ar­yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(thio­phen-2-yl)prop-2-en-1-ones and thio­semicarbazide leads to the formation of reduced 3,4′-bi­pyrazole-2-carbo­thio­amides.
Manju, Nagaraja, Yathirajan, Hemmige S., Harish Chinthal, Chayanna, Chinthal, Chayanna Harish, Kalluraya, Balakrishna, Foro, Sabine, Yathirajan, H. S., Glidewell, Christopher, Nagaraja Manju, Sabine Foro, Chayanna Harish Chinthal, Christopher Glidewell, Hemmige S. Yathirajan, Balakrishna Kalluraya   +13 more
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Expanded access to psychedelic treatments: comparing American and Canadian policies

General Psychiatry, Volume 38, Issue 1, February 2025.
Jérémie Richard, Albert Garcia‐Romeu, Jack E Henningfield   +2 more
wiley   +1 more source

Pharmacokinetic parameters of MDMA, MDA, HMMA, and duloxetine.

, 2012
Cmax, maximum plasma concentration; Tmax, time from drug administration to maximum plasma concentration; AUC0-∞, area under concentration-time curve extrapolated to infinity.
Marius C. Hoener (166578), Cédric M. Hysek (166535), Linda D. Simmler (166540), Massimiliano Donzelli (166552), Valentina G. Nicola (166543), Stephan Krähenbühl (166557), Nerina Vischer (166548), Jörg Huwyler (166572), Eric Grouzmann (166564), Matthias E. Liechti (166584)   +9 more
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Necrosamine Series. II.* Synthesis of Racemic 4,5-Diaminoeicosane and of 2-Methyl-3,4-diaminononadecane [PDF]

, 1956
Racemic 4,5-diaminoeicosane (I) and 2-methyl-3,4-diaminononadecane (II) were obtained by reaction of dibenzyl sodiotetradecylmalonate (III) with N-phthaloyl-DL-norvalinoyl chloride (IVa) and N-phthaloyl-DL-valinoyl chloride (IVb).
Alaupović, P., Proštenik, M-
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Gas chromatographic mass spectrometric assay for profiling the enantiomers of 3,4-methylenedioxymethamphetamine and its chiral metabolites using positive chemical ionization ion trap mass spectrometry

, 1997
A qualitative GC/MS profile was obtained and its mass spectrometric features characterized for the analysis of the enantiomers of (RS)-3-4-methylenedioxymethamphetamin (MDMA) and its metabolites (RS)-3,4-methleenedioxyamphetamine (ha)A), (RS)-4-hydroxy-3-
vandeWal, RMA, Maes, RAA, deBruijn, EA, Gorter, P, Tan, LP, deBoer, D, KettenesvandenBosch, JJ   +6 more
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Crystal structure of a fluoro analogue of 3,4-(methylenedioxy)amphetamine

, 2015
cited By 0International audienceThe X-ray crystal structure of 6-fluoro-3,4-methylenedioxyamphetamine hydrochloride, a fluoro analogue of 3,4-(methylenedioxy)amphetamine, was established.
Pinaud, N., Moreau, S., Ronga, Luisa, Benazzouz, A., Guillon, J., Marchivie, M.   +5 more
core  

Streamlined Synthesis of 6-((1H-1,2,3-Triazol-4-yl)methyl)-1H-pyrrolo [3,4-d]pyridazin-1-one System via Sequential N-Alkylation, CuAAC, and [4 + 2] Cyclization Reactions

, 2019
An efficient sequential three-step reaction methodology for the synthesis of three new series-1-(prop-2-yn-1-yl)-1H-pyrroles, methyl 4-acetyl-1-((1H-1,2,3-triazol-4-yl)methyl)-1H-pyrrole-3-carboxylates and 6-((1H-1,2,3-triazol-4-yl)methyl)-2,6-dihydro-1H-
Clarissa P. Frizzo (1457206), Hernane T. Magalhães (6745025), Manfredo Hoerner (6161858), Nilo Zanatta (1457224), Gean M. Dal Forno (6745028), Helio G. Bonacorso (1457209), Marcos A. P. Martins (1457212), Francieli M. Libero (6745031)   +7 more
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