Results 11 to 20 of about 13,980,406 (134)

From Efficacy to Effectiveness: Evaluating Psychedelic Randomized Controlled Trials for Trustworthy Evidence‐Based Policy and Practice

Pharmacology Research & Perspectives
The recent review of a new drug application for MDMA‐assisted therapy for posttraumatic stress disorder by the United States' Food and Drug Administration (FDA) highlighted epistemological and methodological challenges for evidence assessments.
Eduardo Ekman Schenberg
doaj   +2 more sources

Trends in toxicological findings and drug seizures of MDMA in New Zealand from 2010 to 2022. [PDF]

J Forensic Sci
Abstract 3,4‐Methylenedioxymethamphetamine (MDMA) or “ecstasy,” is a commonly used drug worldwide, including in New Zealand, where 4.8% of the population aged 15 years or over reported using it in a 2023/2024 survey. This study provides additional insights on MDMA prevalence data in New Zealand by reporting toxicology data from Coronial and driving ...
Sheehan TJ, Hamnett HJ, Russell SGG, Kappatos D, Poulsen H.   +4 more
europepmc   +2 more sources

Recreational Drug Use at a Music Festival: A Dual Approach Using Hair Biomarkers Analysis and Participant Self-Reported Drug Use. [PDF]

Drug Test Anal
Combined self‐report and hair analysis in festival attendees (n = 249) revealed substantial discrepancies in drug use reporting, particularly for stimulants and dissociatives. This integrated approach enhances detection of poly‐drug use and provides a more reliable basis for monitoring and harm‐reduction strategies.
Simão AY, Rosado T, Barroso M, Andraus M, Gallardo E.   +4 more
europepmc   +2 more sources

Therapeutic Effects of Propolis Supplementation on the Inflammatory State, Oxidative Stress, and Uremic Toxins in dialysis Patients: A Systematic Review. [PDF]

Food Sci Nutr
This systematic review of 6 clinical trials (n = 225) demonstrates that Propolis supplementation (200–400 mg/day for 2–6 months) significantly reduces key inflammatory cytokines TNF‐α, IL‐8, IL‐17, IFN‐γ, and oxidative stress (oxLDL) in dialysis patients.
Mardani M, Ostadrahimi A, Farshbaf-Khalili A.   +2 more
europepmc   +2 more sources

Impact of cytochrome P450 2D6 function on the chiral blood plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its phase I and II metabolites in humans [PDF]

, 2016
3,4-methylenedioxymethamphetamine (MDMA; ecstasy) metabolism is known to be stereoselective, with preference for S-stereoisomers. Its major metabolic step involves CYP2D6-catalyzed demethylenation to 3,4-dihydroxymethamphetamine (DHMA), followed by ...
Tingelhoff, Eva H., Eva H. Tingelhoff, Schmidhauser, Corina, Steuer, Andrea E, Yasmin Schmid (3181563), Eva H. Tingelhoff (3181572), Schmid, Yasmin, Tingelhoff, Eva H, Andrea E. Steuer (1712023), Anna Rickli (3181569), Yasmin Schmid, Anna Rickli, Thomas Kraemer (271037), Liechti, Matthias E., Matthias E Liechti, Liechti, Matthias E, Corina Schmidhauser, Andrea E. Steuer, Rickli, Anna, Matthias E. Liechti (166584), Eva H Tingelhoff, Thomas Kraemer, Andrea E Steuer, Corina Schmidhauser (3181566), Steuer, Andrea E., Matthias E. Liechti, Kraemer, Thomas, Rickli A, Kraemer T, Steuer AE, Schmidhauser C, Tingelhoff EH, Schmid Y, Liechti ME   +33 more
core   +1 more source

The synthesis and identification of previously unreported artefacts formed during phosgene-contaminated chloroform extraction of amphetamine-type substances

, 2020
Amphetamine-type substances (ATS) are the most common illicit drugs synthesised in domestic clandestine laboratories. Liquid-liquid extraction of exhibits remains a key step in the analysis of exhibits, with chloroform often the solvent of choice in ...
Miller, Brendan, Boyd, Sue E, Brendan Miller, Sue E. Boyd   +3 more
core   +1 more source

N′-Acetyl-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide

, 2020
Synthesis of N′-acetyl-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide from the phenyl acetates of 3-acetyl-5-(3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-yl)-2,3-dihydro-1,3,4-oxadiazol-2-yl in alkaline medium and its ...
Luiza R. S. Dias, Júlio C. A. V. Soares
core   +1 more source

(+/-)3,4-Methylenedioxyamphetamine inhibits the TEA-sensitive K+ current in the hippocampal neuron and the Kv2.1 current expressed in H1355 cells

, 2017
The whole-cell patch clamp method was used to study the effects of (+/-)3,4-methylenedioxyamphetamine (MDA) in hippocampal CM neurons from neonatal rats and in lung epithelial H1355 cells expressing Kv2.1.
蔡明正, Lin, Chia-Hsien;Yang, Chin-Tsang;Tsai, Ming-Cheng;Wu, Ya-Ting;MacDonald, Iona;Wang, Mei-Ling;Wu, Chien-Hua;Leung, Yuk-Man;Chen, Yi-Hung   +1 more
core   +1 more source

Action Spectroscopy of Mass‐Selected Ions—From Principles to Applications

Journal of Mass Spectrometry, Volume 61, Issue 10, October 2026.
ABSTRACT Gas‐phase ion spectroscopy provides direct, structure‐sensitive information that complements and extends conventional mass spectrometry workflows, offering structural resolution that accurate mass and fragmentation patterns alone cannot always achieve by themselves.
Pedro Henrique Martins Garcia, Gustavo Cervi, Cesar Augusto Gonçalves Dantas, Guilherme Obeid, Thiago C. Correra   +4 more
wiley   +1 more source

Selective Detection of Methamphetamine Hydrochloride Using Fluorescent Benzo[ghi]perylenetriimide Thin Films in a Single‐Channel Detector·

Advanced Sensor Research, Volume 5, Issue 9, September 2026.
This study reports fluorescent benzo[ghi]perylenetriimide films incorporated into a simple device architecture that can selectively detect methamphetamine hydrochloride (MA•HCl) over 3,4‐methylenedioxyamphetamine hydrochloride, cocaine hydrochloride, and fentanyl hydrochloride with a limit of detection of 10 ng.
Shengqiang Fan, Guanran Zhang, Oliver Lindsay, Paul L. Burn, Ian R. Gentle, Paul E. Shaw   +5 more
wiley   +1 more source