Results 141 to 150 of about 10,083 (200)
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MDMA and MDMA-Assisted Therapy
American Journal of PsychiatryMDMA (i.e., 3,4-methylenedixoymethamphetamine), commonly known as "Ecstasy" or "Molly," has been used since the 1970s both in recreational and therapeutic settings. The Food and Drug Administration (FDA) designated MDMA-Assisted Therapy (MDMA-AT) as a Breakthrough Therapy for posttraumatic stress disorder (PTSD) in 2017, and the FDA is requiring an ...
Carolyn Rodríguez, John Krystal
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2023
Abstract MDMA (3,4-methylenedioxymethamphetamine) was originally synthesized and patented by the Merck chemical company in 1914. It was not explored for human use until the 1970–80s when there were published reports that it could be a useful catalyst to psychotherapy, in part because it often produced reduced anxiety and increased ...
Michael C. Mithoefer, David E. Presti
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Abstract MDMA (3,4-methylenedioxymethamphetamine) was originally synthesized and patented by the Merck chemical company in 1914. It was not explored for human use until the 1970–80s when there were published reports that it could be a useful catalyst to psychotherapy, in part because it often produced reduced anxiety and increased ...
Michael C. Mithoefer, David E. Presti
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The role of extracellular serotonin and MDMA in the sensitizing effects of MDMA
Behavioural Brain Research, 2022MDMA is a non-selective monoamine releasing stimulant with potent serotonergic effects - a pharmacological effect not typically associated with drugs of misuse or efficacious reinforcers. Nonetheless, MDMA is misused by humans and self-administered by laboratory animals.
Ross, van de Wetering +5 more
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Annals of Clinical Psychiatry, 2007
3,4-Methylenedioxymethamphetamine (MDMA or Ecstasy) is a synthetic amphetamine analogue that is recreationally used to obtain a psychological effect of enhanced affiliative emotional response. Its use in Western countries appears to be increasing, particularly among young individuals.Pertinent basic and clinical literature is critically reviewed.A ...
Rif S, El-Mallakh, Henry David, Abraham
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3,4-Methylenedioxymethamphetamine (MDMA or Ecstasy) is a synthetic amphetamine analogue that is recreationally used to obtain a psychological effect of enhanced affiliative emotional response. Its use in Western countries appears to be increasing, particularly among young individuals.Pertinent basic and clinical literature is critically reviewed.A ...
Rif S, El-Mallakh, Henry David, Abraham
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The subjective effects of MDMA and mCPP in moderate MDMA users
Drug and Alcohol Dependence, 2001The present study is part of a research program designed to better understand the neurochemical mechanisms underlying the abuse liability of 3,4-methylenedioxymethamphetamine (MDMA) in humans. In these studies, MDMA will be compared to prototypical dopamine (D-amphetamine) and serotonin (meta-chlorophenylpiperazine, mCPP) releasing agents on a variety ...
M E, Tancer, C E, Johanson
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2021
Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine, and mescaline, and entactogens/empathogens, especially 3,4-methylenedioxymethamphetamine, have received renewed attention in psychiatric research and may be developed into medications for such indications as anxiety, depression, cluster headache, and ...
Liechti, Matthias E., Holze, Friederike
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Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine, and mescaline, and entactogens/empathogens, especially 3,4-methylenedioxymethamphetamine, have received renewed attention in psychiatric research and may be developed into medications for such indications as anxiety, depression, cluster headache, and ...
Liechti, Matthias E., Holze, Friederike
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Abstract MDMA (3,4-methylenedioxymethamphetamine), although not considered to be a “classic” psychedelic, has been of particular interest for some time now as an agent for use in psychedelic-assisted therapy. Much of the research in recent years has focused on its potential applications in managing post-traumatic stress disorder ...
Elisha Waldman +3 more
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Elisha Waldman +3 more
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Pharmacology of MDMA in Humans
Annals of the New York Academy of Sciences, 2000AbstractMDMA given at recreational doses (range tested 50 to 150 mg) to healthy volunteers, produced mydriasis and marked increases in systolic and diastolic blood pressure, heart rate, and pupillary diameter. MDMA induced changes on oral temperature. The time course of this observation was biphasic, as a slight decrease at 1 h and a slight increase at
, de la Torre R +9 more
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Immunomodulating Activity of MDMA
Annals of the New York Academy of Sciences, 2000AbstractMDMA (3,4‐methylenedioxymethamphetamine) use can cause neurochemical, behavioral and endocrine alterations, similar to those produced by exposure to acute stress, suggesting its potential as a “chemical stressor.” It is known that stressful stimuli can produce a depression of immune function and an alteration in immune cells distribution.In ...
R, Pacifici +10 more
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Increased responsiveness to MDMA in adult rats treated neonatally with MDMA
Neurotoxicology and Teratology, 2006MDMA [(+/-)3,4-methylenedioxymethamphetamine, also known as ecstasy] is a popular recreational drug among women of reproductive age. The objective of this study was to investigate the long-term neurobehavioral consequences of early developmental MDMA exposure. On postnatal days (PD) 1-4, Sprague-Dawley rats received two 10 mg/kg injections of MDMA with
Brian J, Piper, Jerrold S, Meyer
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