Results 221 to 230 of about 40,945 (273)

Acute subjective effects in LSD- and MDMA-assisted psychotherapy

Journal of Psychopharmacology, 2020
Background: Lysergic acid diethylamide (LSD) and 3,4-methylenedioxymethamphetamine (MDMA) were used in psychotherapy in the 1960s–1980s, and are currently being re-investigated as treatments for several psychiatric disorders.
Y. Schmid, Peter Gasser, Peter Oehen, M. Liechti   +3 more
semanticscholar   +1 more source

MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens

Science Advances
MDMA (3,4-methylenedioxymethamphetamine) is a psychoactive drug with powerful prosocial effects. While MDMA is sometimes termed an “empathogen,” empirical studies have struggled to clearly demonstrate these effects or pinpoint underlying mechanisms. Here,
Ben Rein, Kendall B. Raymond, Cali Boustani, Sabrena Tuy, Jie Zhang, Robyn St. Laurent, Matthew B. Pomrenze, Parnaz Boroon, B. Heifets, Monique Smith, Robert C. Malenka   +10 more
semanticscholar   +1 more source

Therapeutic effect of increased openness: Investigating mechanism of action in MDMA-assisted psychotherapy

Journal of Psychopharmacology, 2017
A growing body of research suggests that traumatic events lead to persisting personality change characterized by increased neuroticism. Relevantly, enduring improvements in Post-Traumatic Stress Disorder (PTSD) symptoms have been found in response to 3,4-
Rebecca K Macaulay, Lisa Jerome
exaly   +2 more sources

Efficacy of Psychoactive Drugs for the Treatment of Posttraumatic Stress Disorder: A Systematic Review of MDMA, Ketamine, LSD and Psilocybin

Journal of Psychoactive Drugs, 2020
The aim of this systematic review was to examine the efficacy of MDMA, ketamine, LSD, and psilocybin for the treatment of posttraumatic stress disorder (PTSD).
T. Varker, Loretta Watson, Kari Gibson, D. Forbes, M. O'Donnell   +4 more
semanticscholar   +1 more source

A comparison of MDMA-assisted psychotherapy to non-assisted psychotherapy in treatment-resistant PTSD: A systematic review and meta-analysis

Journal of Psychopharmacology, 2020
Rationale: Novel, evidence-based treatments are required for treatment-resistant post-traumatic stress disorder (PTSD). 3,4-Methylenedioxymethamphetamine (MDMA) has beneficially augmented psychotherapy in several small clinical trials.
B. Illingworth, Declan J Lewis, A. Lambarth, K. Stocking, J. Duffy, L. Jelen, J. Rucker   +6 more
semanticscholar   +1 more source

Dosing Psychedelics and MDMA

2021
Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine, and mescaline, and entactogens/empathogens, especially 3,4-methylenedioxymethamphetamine, have received renewed attention in psychiatric research and may be developed into medications for such indications as anxiety, depression, cluster headache, and ...
Liechti, Matthias E., Holze, Friederike
openaire   +3 more sources

Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

Pediatric Emergency Care, 2000
Ecstasy (MDMA) is an amphetamine derivative of growing popularity. The drug produces a range of toxicities when taken either in standard doses or overdose. In overdose it has major toxicity, producing several different life-threatening manifestations. Hepatotoxicity and hyponatremia are common but poorly understood consequences of MDMA overdose.
openaire   +2 more sources

MDMA

Abstract MDMA (3,4-methylenedioxymethamphetamine), although not considered to be a “classic” psychedelic, has been of particular interest for some time now as an agent for use in psychedelic-assisted therapy. Much of the research in recent years has focused on its potential applications in managing post-traumatic stress disorder ...
Elisha Waldman, Monica Romanko, Mark Skellie, Mark Bates   +3 more
openaire   +2 more sources

Ecstasy (MDMA) dependence

Drug and Alcohol Dependence, 1999
Methylenedioxymethamphetamine (MDMA) is generally described as non-addictive. However, this report describes three cases in which criteria for dependence were met. A wider understanding that MDMA can be addictive in rare cases is important as very heavy use may cause lasting neuronal changes. This risk could be reduced with effective identification and
openaire   +2 more sources

MDMA interactions with pharmaceuticals and drugs of abuse

Expert Opinion on Drug Metabolism & Toxicology, 2020
Introduction: MDMA (3,4-methylenedioxymethamphetamine), a synthetic ring-substituted amphetamine, has become one of the most widely used recreational psychostimulant drugs in the world.
E. Papaseit, C. Pérez-Mañá, M. Torrens, A. Farré, Lourdes Poyatos, O. Hladun, A. Sanvisens, Roberto Muga, M. Farré   +8 more
semanticscholar   +1 more source