Results 171 to 180 of about 159,394 (277)

Responsible use of new antibiotics for critically ill patients suffering from infections due to carbapenem-resistant organisms-a narrative review for an enablement strategy. [PDF]

JAC Antimicrob Resist
Eckmann C, Akova M, Antonelli M, Bassetti M, Cantón R, Dryden M, Falcone M, Kanj SS, Kiertiburanakul S, Gilchrist M, Montravers P, Paterson DL, Senneville E, Soriano A, Timsit JF, Villegas MV, Viale P.   +16 more
europepmc   +1 more source

A Lived Experience Perspective on Digital Regulatory Practices

Journal of Psychiatric and Mental Health Nursing, EarlyView.
ABSTRACT The paper reflects on a Wellcome‐funded project led by the Medicines and Healthcare products Regulatory Agency (MHRA) in collaboration with the National Institute for Health and Care Excellence (NICE). Initiated in 2023, the project aimed at developing guidance and regulatory frameworks for digital mental health technologies (DMHTs ...
Holly Coole, Grace Gatera, Ellen Thomas
wiley   +1 more source

Biocontrol potential and genomic analysis of novel lytic bacteriophage CABI-SEA 2302 against multidrug-resistant avian pathogenic Escherichia coli associated with colibacillosis. [PDF]

Poult Sci
Bilhman S, Paosen S, Limsatanun A, Waeoh A, Pattano J, Voravuthikunchai SP, Lethongkam S.   +6 more
europepmc   +1 more source

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source

When are large language models medical devices? Navigating the MDR and AI Act for healthcare applications. [PDF]

BMJ Digit Health Ai
Workum JD, Krijgsman SJ, Vajda I, Van Stokkum RM, van de Brand J, Gommers D, Ercole A, van Genderen M.   +7 more
europepmc   +1 more source

Occurrence of infections in dogs receiving ciclosporin in a single‐centre UK referral population

Journal of Small Animal Practice, EarlyView.
Objectives The study aimed (a) to describe the occurrence and nature of new infections in dogs receiving oral ciclosporin and (b) to identify any risk factors associated with the development of a new infection whilst receiving ciclosporin. Materials and Methods In this retrospective cohort study, medical records of dogs presented to a private UK ...
S. Dormon, J. Walker, G. Gallow, L. Goonan, T. Sparks, A. Paul   +5 more
wiley   +1 more source

Type IV‐Dominated Plasmid‐Encoded CRISPR‐Cas Systems Are Enriched in Multireplicon and Multi‐Stressor Resistance Plasmids Across the Global Plasmidome

Molecular Microbiology, EarlyView.
Screening 72,555 plasmid sequences reveals that intact CRISPR‐Cas systems are rare (1.03%) but strongly enriched in multireplicon and multi‐stressor resistance plasmids, with Type IV‐A as the dominant subtype. These findings implicate plasmid‐encoded CRISPR‐Cas as non‐randomly retained elements of structurally complex and high‐risk backbones.
Hannay Crystynah Almeida de Souza, Anamaria Mota Pereira dos Santos, Arlen Carvalho de Oliveira Almeida, Carlos Adam Conte Junior, Pedro Panzenhagen   +4 more
wiley   +1 more source

Evaluation of pyocin activity and pyocin-related gene distribution in multidrug- and extensively drug-resistant <i>Pseudomonas aeruginosa</i> isolates from Thailand. [PDF]

PeerJ
Laosena P, Suppaiboolkij P, Nualnisachol P, Walker D, Premsuriya J.   +4 more
europepmc   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source