Results 81 to 90 of about 159,394 (277)

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

Analysis of clinical investigation (device) initial submissions received by the Medicines and Healthcare products Regulatory Agency between January 2022 and December 2025

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse clinical investigation‐device initial submissions received by the MHRA between January 2022 and December 2025. Methods Data on submissions were extracted from the clinical investigations unit data bank; software as medical devices were not included. The predefined primary end‐point was submission type.
Andrea Manfrin, Mark Grumbridge, Daniel Hill, Crina Cacou, Graham Warren, James Pound, Jacob George, Alejandro F. Frangi   +7 more
wiley   +1 more source

Bacteriological Profile and Antimicrobial Susceptibility Patterns of Gram-Negative Bloodstream Infection and Risk Factors Associated with Mortality and Drug Resistance: A Retrospective Study from Shanxi, China

Infection and Drug Resistance, 2022
Nan Shi,1,2,* Jianbang Kang,2,* Shuyun Wang,2 Yan Song,2 Donghong Yin,2 Xiaoxia Li,2 Qian Guo,2 Jinju Duan,2 Shuqiu Zhang1 1Department of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of Pharmacy ...
Shi N, Kang J, Wang S, Song Y, Yin D, Li X, Guo Q, Duan J, Zhang S   +8 more
doaj  

Bildungsurlaub in Sachsen: Kritik von Unternehmen wegen finanzieller Belastung

Ein Beitrag im Programm "MDR AKTUELL – Das Nachrichtenradio" vom 30.06 ...
Schmidt-Lauff, Sabine, Seifert, André
core   +1 more source

Electron compensation‐gated nanomotor for immunomodulation and microenvironment remodeling in bacterial pneumonia therapy

BMEMat, EarlyView.
A nanomotor featuring an “electronic lock” via electron compensation in an Au‐Ag alloy ensures therapeutic precision. Near‐infrared light acts as a key, unlocking on‐demand Ag+ release for synergistic bactericidal action and microenvironment remodeling to potently treat bacterial pneumonia. Abstract Bacterial pneumonia treatment is severely hampered by
Chenglong Xue, Xiaoyu Zhao, Yuqian Wang, Lijin Shi, Qi Shuai   +4 more
wiley   +1 more source

Distribution of MDR Cases across Diagnostic Centres (where at least 1 MDR-TB case was found).

, 2016
Distribution of MDR Cases across Diagnostic Centres (where at least 1 MDR-TB case was found).
Olga Tosas (171346), Chris Coulter (2579359), Margaret Kal (2579362), Karen Johnson (464381), Julia Ershova (841506), Tauhid Islam (2579365), Paul Aia (2579353), Evelyn Lavu (666539), Lucy N. John (2579356), Matteo Zignol (94959), Shalala Ahmadova (2579350)   +10 more
core   +1 more source

From Double Materiality to Performance: Conceptualizing Reporting Under the European Sustainability Reporting Standards

Business Strategy and the Environment, EarlyView.
ABSTRACT As social and environmental challenges intensify, the EU has introduced the Corporate Sustainability Reporting Directive (CSRD), mandating sustainability reporting through the European Sustainability Reporting Standards (ESRS). The standards mandate a double materiality assessment but leave uncertainty about the structure and contents of the ...
Jørgen Kjøsen Lindgren, Nora Johanne Klungseth, Bjørn Sørskot Andersen   +2 more
wiley   +1 more source

Combination therapy for carbapenem-resistant gram-negative infections in Ukraine

Infusion & Chemotherapy
. Antimicrobial resistance represents a serious global public health problem and poses a major challenge in the management of combat-related injuries during armed conflicts, such as the war of Russia against Ukraine.
O.V. Moshynets, V.V. Strokous, M.I. Valihurskyi, M.M. Cherniienko, O.V. Kotov, O.A. Golubovska, A.O. Oberniak, F.S. Nikitenko, O.S. Iungin, V.V. Potochilova, K.L. Rudnieva, M.V. Khaitovych   +11 more
doaj   +1 more source

Monitoring the Burden of the Antibiotic Resistance and Virulence Genes in Pet Animals Suffering from Bacterial Otitis [PDF]

Journal of Applied Veterinary Sciences
The etiology of otitis in dogs and cats is multifactorial and complex, involving bacterial and fungal pathogens. This study aimed to describe microbiological features and susceptibility profiles of bacterial pathogens associated with 212 cases of ...
Mayson Hamdy, Soliman Mohammed, Haithem Farghali, Hassan Aboul-Ella, Sherif Marouf   +4 more
doaj   +1 more source

Human Agency Drivers for Eco‐Innovation: The Role of Environmental Entrepreneurship Orientation and Green Human Resource Management

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how human agency drives eco‐innovation by analyzing the mediating role of green human resource management (HRM) in the relationship between environmental entrepreneurship orientation (EEO) and eco‐innovation. By integrating resource orchestration theory with the Ability–Motivation–Opportunity (AMO) framework, the study ...
Ana Labella‐Fernández, Diego A. Vazquez‐Brust, Javier Martínez‐del‐Río, Rui Yang   +3 more
wiley   +1 more source