Results 1 to 10 of about 23,574 (151)

‘Z S -MDR-TB’ versus ‘Z R -MDR-TB’: improving treatment of MDR-TB by identifying pyrazinamide susceptibility

Emerging Microbes and Infections, 2012
Indispensable for shortening treatment of drug-susceptible tuberculosis (TB), pyrazinamide (PZA, Z) is also essential in the treatment of multidrug-resistant (MDR)-TB. While resistance to PZA in MDR-TB is associated with poor treatment outcome, bacillary
Wenhong Zhang, Kwok-Chiu Chang, Dorothy Fallows   +2 more
exaly   +3 more sources

High-dose gatifloxacin-based shorter treatment regimens for MDR/RR-TB

International Journal of Infectious Diseases, 2022
Setting: The shorter treatment regimen (STR) for multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) has achieved successful outcomes in many countries.
Qi Nie, Lixuan Tao, Yingying Li, Nanshan Chen, Hua Chen, Yong Zhou, Yanqiu Wang, Huidong Chen, Qiuping Tang, Xianguang Wang, Chaolin Huang, Chengfeng Yang   +11 more
doaj   +1 more source

Phenotypic drug susceptibility characterization and clinical outcomes of tuberculosis strains with A-probe mutation by GeneXpert MTB/RIF

BMC Infectious Diseases, 2023
Background GeneXpert MTB/RIF (Xpert) assay was applied widely to detect Mycobacterium tuberculosis (MTB) and rifampicin resistance. Methods Retrospectively investigated the association among treatment histories, phenotypic drug susceptibility testing ...
Qi Nie, Dan Sun, Muxin Zhu, Shengjin Tu, Nanshan Chen, Hua Chen, Yong Zhou, Ge Yao, Xiaoqing Zhang, Tongcun Zhang, Chengfeng Yang, Lixuan Tao   +11 more
doaj   +1 more source

Disease control implications of India's changing multi-drug resistant tuberculosis epidemic. [PDF]

PLoS ONE, 2014
Multi-drug resistant tuberculosis (MDR TB) is a major health challenge in India that is gaining increasing public attention, but the implications of India's evolving MDR TB epidemic are poorly understood.
Sze-Chuan Suen, Eran Bendavid, Jeremy D Goldhaber-Fiebert   +2 more
doaj   +1 more source

Intra-urban variation in tuberculosis and community socioeconomic deprivation in Lisbon metropolitan area: a Bayesian approach

Infectious Diseases of Poverty, 2022
Background Multidrug resistant tuberculosis (MDR-TB) is a recognized threat to global efforts to TB control and remains a priority of the National Tuberculosis Programs. Additionally, social determinants and socioeconomic deprivation have since long been
Olena Oliveira, Ana Isabel Ribeiro, Raquel Duarte, Margarida Correia-Neves, Teresa Rito   +4 more
doaj   +1 more source

Global trends in the incidence rates of MDR and XDR tuberculosis: Findings from the global burden of disease study 2019

Frontiers in Pharmacology, 2023
Purpose: The study aimed to quantify the global trends of the incidence rates of multidrug-resistant (MDR) tuberculosis (MDR-TB) and extensively drug-resistant (XDR) tuberculosis (XDR-TB).Methods: Cases, age-standardized rates (ASRs), and incidence rates
Qingting Bu, Rong Qiang, Lingyan Fang, Xiaokang Peng, Hua Zhang, Hua Cheng   +5 more
doaj   +1 more source

Project extension for community healthcare outcomes improves care and treatment for multidrug-resistant tuberculosis patients in Tanzania

International Journal of Mycobacteriology, 2021
Background: Project Extension for Community Healthcare Outcomes (Project ECHO) is a telementoring, case based virtual community of practice training and education model connecting experts to primary care clinicians (PCCs).
Daud Dunstan Peter, Shabani Ramadhani Mziray, Isack Augustino Lekule, Victor Kitundu, Salum Mohamed, Riziki Michael Kisonga, Stellah George Mpagama, Bruce Baird Struminger   +7 more
doaj   +1 more source

Discrepancy in the transmissibility of multidrug-resistant mycobacterium tuberculosis in urban and rural areas in China

Emerging Microbes and Infections, 2023
The fitness of multidrug-resistant tuberculosis (MDR-TB) is thought to be an important determinant of a strain’s ability to be transmitted. Studies in the laboratory have demonstrated that MDR-TB strains have reduced fitness but the relative ...
Meng Li, Liping Lu, Mingcheng Guo, Qi Jiang, Lan Xia, Yuan Jiang, Shu Zhang, Yong Qiu, Chongguang Yang, Yiwang Chen, Jianjun Hong, Xiaoqin Guo, Howard Takiff, Xin Shen, Chuang Chen, Qian Gao   +15 more
doaj   +1 more source

Multidrug-resistant tuberculosis surveillance and cascade of care in Madagascar: a five-year (2012–2017) retrospective study

BMC Medicine, 2020
Background In Madagascar, the multidrug-resistant tuberculosis (MDR-TB) surveillance programme was launched in late 2012 wherein previously treated TB cases and symptomatic MDR-TB contacts (hereafter called presumptive MDR-TB cases) undergo drug ...
Astrid M. Knoblauch, Simon Grandjean Lapierre, Daniella Randriamanana, Mamy Serge Raherison, Andrianantenaina Rakotoson, Bienvenue Solofomandimby Raholijaona, Masiarivony Ravaoarimanga, Pascaline Elisabeth Ravololonandriana, Marie-Sylvianne Rabodoarivelo, Orelys Ratsirahonana, Fanjasoa Rakotomanana, Turibio Razafindranaivo, Voahangy Rasolofo, Niaina Rakotosamimanana   +13 more
doaj   +1 more source

Self-reported risks for multiple-drug resistance among new tuberculosis cases: implications for drug susceptibility screening and treatment. [PDF]

PLoS ONE, 2011
BACKGROUND: Multiple drug-resistance in new tuberculosis (TB) cases accounts for the majority of all multiple drug-resistant TB (MDR-TB) worldwide. Effective control requires determining which new TB patients should be tested for MDR disease, yet the ...
Timothy F Brewer, Howard W Choi, Carlos Seas, Fiorella Krapp, Carlos Zamudio, Lena Shah, Antonio Ciampi, S Jody Heymann, Eduardo Gotuzzo   +8 more
doaj   +1 more source