Results 41 to 50 of about 260,092 (192)

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Advanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu, Xiaoxu Zhang, Xi Chen, Yifan Luo, Zhong Zuo, Ronald Man Yeung Wong, Miao Xu, Tiancong Zhao, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru

Emerging Infectious Diseases, 2011
Two cases of multidrug-resistant tuberculosis (MDR TB) in a household are assumed to reflect within-household transmission. However, in high-incidence areas of MDR TB, secondary cases may arise through exposure to MDR TB in the community. To estimate the
Ted Cohen, Megan B. Murray, Ibrahim Abubakar, Zibiao Zhang, Alexander Sloutsky, Fernando Arteaga, Katiuska Chalco, Molly F. Franke, Mercedes C. Becerra   +8 more
doaj   +1 more source

Operational challenges in diagnosing multi-drug resistant TB and initiating treatment in Andhra Pradesh, India. [PDF]

PLoS ONE, 2011
BACKGROUND: Revised National TB Control Programme (RNTCP), Andhra Pradesh, India. There is limited information on whether MDR-TB suspects are identified, undergo diagnostic assessment and are initiated on treatment according to the programme guidelines ...
Sarabjit S Chadha, B N Sharath, Kishore Reddy, Jyothi Jaju, P H Vishnu, Sreenivas Rao, Malik Parmar, Srinath Satyanarayana, Kuldeep Singh Sachdeva, Nevin Wilson, Anthony D Harries   +10 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Transmission of multidrug-resistant tuberculosis in the UK: a cross-sectional molecular and epidemiological study of clustering and contact tracing [PDF]

, 2014
BACKGROUND: Between 2000 and 2012 the number of multidrug-resistant (MDR) tuberculosis cases in the UK increased from 28 per year to 81 per year. We investigated the proportion of MDR tuberculosis cases arising from transmission in the UK and associated ...
Abubakar, Ibrahim, Anderson, Laura F, Brown, Timothy, Watson, JP, Abubakar, I, Tamne, Surinder, Mullarkey, C, Anderson, LF, Tamne, S, Zenner, D, Brown, T, Mullarkey, Catherine, Watson, John P, Zenner, Dominik   +13 more
core   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

PEMETAAN KASUS MULTIDRUG RESISTANT TUBERCULOSIS(MDR-TB) DI KALIMANTAN BARAT [PDF]

, 2021
Penyakit Tuberkulosis (TB) masih menjadi prioritas utama di dunia dan menjadi salah satu target dalam SDGs (Sustainability Development Goals). Pengobatan TB yang tidak memadai dapat meningkatkan risiko resistansi kuman terhadap Obat Anti TB (OAT), salah ...
Debataraja, Naomi Nessyana, Yudhi, Yudhi, Septiani, Zettira   +2 more
core   +1 more source

Multidrug-Resistant Tuberculosis 
Outbreak among US-bound Hmong 
Refugees, Thailand, 2005

Emerging Infectious Diseases, 2008
In January 2005, tuberculosis (TB), including multidrug-resistant TB (MDR TB), was reported among Hmong refugees who were living in or had recently immigrated to the United States from a camp in Thailand.
John E. Oeltmann, Jay K. Varma, Luis Ortega, Yecai Liu, Thomas O’Rourke, Maria Cano, Theresa A. Harrington, Sean Toney, Warren Jones, Samart Karuchit, Lois Diem, Dhanida Rienthong, Jordan W. Tappero, Kashef Ijaz, Susan A. Maloney   +14 more
doaj   +1 more source

Food Contamination and Safety in Nigeria: A Systematic Synthesis of Heavy Metals, Microbial Pathogens, and Health Risk Metrics

Food Safety and Health, EarlyView.
This is an infographic driver of food contaminants and health effects. ABSTRACT Food safety remains a critical challenge in Nigeria due to rapid urbanization and weak regulatory enforcement. This systematic review synthesizes empirical evidence from 2015 to 2025 to characterize food contaminant profiles and associated human health risks in Nigeria ...
Cecilia Nwadiuto Obasi, Naomi A. Mogborukor, Baridoo Donatus Dooka, Polycarp Dauda Madaki, Chiara Frazzoli, Mohamed Haddad, Orish Ebere Orisakwe   +6 more
wiley   +1 more source

Multidrug-resistant Mycobacterium tuberculosis and associated risk factors in Oromia Region of Ethiopia

International Journal of Infectious Diseases, 2015
Objective: The aim of this study was to determine risk factors for tuberculosis (TB) caused by multidrug-resistant Mycobacterium tuberculosis (MDR-TB) in Oromia Region, Ethiopia. Methods: A 6-month case–control study was performed in 2013–14.
Girma Mulisa, Tilaye Workneh, Niguse Hordofa, Mohamed Suaudi, Gemeda Abebe, Godana Jarso   +5 more
doaj   +1 more source