Results 61 to 70 of about 22,933 (185)

Do we need to detect isoniazid resistance in addition to rifampicin resistance in diagnostic tests for tuberculosis? [PDF]

PLoS ONE, 2014
Multidrug-resistant tuberculosis (MDR-TB) is resistant to both rifampicin (RIF) and isoniazid (INH). Whereas many TB diagnostics detect RIF-resistance, few detect INH-monoresistance, which is common and may increase risk of acquired MDR-TB.
Claudia M Denkinger, Madhukar Pai, David W Dowdy   +2 more
doaj   +1 more source

GeneXpert MTB/RIF Is Superior to BBD Max MDR-TB for Diagnosis of Tuberculosis (TB) in a Country with Low Incidence of Multidrug-Resistant TB (MDR-TB) [PDF]

Journal of Clinical Microbiology, 2019
With 10 million active disease cases, 558,000 cases of rifampin-resistant/multidrug-resistant tuberculosis (MDR-TB), and 1.6 million deaths recorded worldwide in 2017, TB is a leading cause of death from a single infectious agent ([1][1]).
E M, Mokaddas, S, Ahmad, H S, Eldeen
openaire   +2 more sources

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co‐Infected With HIV

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background HIV co‐infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first‐line anti‐TB drugs and clinical outcomes in patients with and without HIV co‐infection. Methods In this prospective observational study, 61 adults with sputum‐positive pulmonary TB, either confirmed ...
Aung Pyae Phyo, Richard M. Hoglund, Makoto Saito, Sein Sein Thi, Lei Lei Swe, Palang Chotsiri, Htet Ko Ko Aung, Win Pa Pa Tun, Banyar Maung Maung, Chanapat Pateekham, Wanitda Watthanaworawit, Gornpan Gornsawun, Nicholas J. White, Francois Nosten, Joel Tarning   +14 more
wiley   +1 more source

Gridlock from diagnosis to treatment of multidrug resistant tuberculosis (MDR-TB) in Tanzania: patients’ perspectives from a focus group discussion

BMC Public Health, 2020
Background Molecular diagnostics have revolutionized the diagnosis of multidrug resistant tuberculosis (MDR-TB). Yet in Tanzania we found delay in diagnosis with more than 70% of MDR-TB patients having a history of several previous treatment courses for ...
Stellah G. Mpagama, Mangi J. Ezekiel, Peter M. Mbelele, Anna M. Chongolo, Gibson S. Kibiki, Kristen Petros de Guex, Scott K. Heysell   +6 more
doaj   +1 more source

One Health Insights From Pteropus medius: Nipah Virus Spillover, Microbiota, and Antimicrobial Resistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Environmental and anthropogenic drivers of antibiotic resistance dissemination. The cycle reinforces how anthropogenic inputs, such as sewage, animal dung, hospital effluent, and agricultural runoff bring resistant bacteria and antibiotic residues into soil and water.
Punam Chowdhury, Shah Md Tanvir Khan, Sajal Roy, Md. Shohel Al Faruk   +3 more
wiley   +1 more source

Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli, Volker Müller, Christoph Welsch, Heiko Mühl, Jonel Trebicka, Volkhard A. J. Kempf   +5 more
wiley   +1 more source

Relationship Five Behavioral Indicators and Healthy Living with Tuberculosis Multidrug-Resistant

Jurnal Berkala Epidemiologi, 2014
Clean and healthy life style is a behavior that is closely related to the emergence of infectious diseases, including TB continued into MDR-TB. This study aimed to determine the relationship between the 5 behavioral indicators of clean and healthy living
Heri Mulyanto
doaj   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an In Vivo Murine Burn Model Study

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source

Evaluasi Penggunaan Algoritma TB-MDR Sebagai Alat Diagnosis TB - MDR Pada Penderita TB

Jurnal Penelitian Keperawatan Kontemporer
Latar Belakang: Kuman yang menyebabkan tuberkulosis dapat menjadi resisten terhadap obat antituberkulosis (OAT) yang digunakan untuk membunuh kuman TB. Hasil dari penelitian yang dilakukan oleh Hidayathillah, 2016 yaitu indeks kejadian TB-MDR, dimana jika terdapat penderita TB maka penderita TB tersebut dapat diprediksi apakah mempunyai risiko tinggi ...
Ariska Putri Hidayathillah, Putri Pamungkas, Aan Raivi   +2 more
openaire   +1 more source