Results 71 to 80 of about 22,933 (185)

Isomer Engineering of NIR‐II Aggregation‐Induced Emission for the Theranostics of MRSA‐Induced Abscess

Aggregate, Volume 7, Issue 6, June 2026.
This work presents a positional isomer engineering strategy to create a microenvironment‐tolerant NIR‐II AIEgen. The para‐isomer exhibits optimized excited‐state dynamics, enabling potent Type‐I photodynamic activity under hypoxia along with photothermal conversion.
Wentian Zhang, Haifei Wen, Ximing Chen, Tianxing Liu, Yuanyuan Li, Zhiliang Yu, Linjie Tan, Shichuang Xu, Parvej Alam, Zheng Zhao, Ying Li, Junfeng Dong, Ben Zhong Tang   +12 more
wiley   +1 more source

Automated Tuberculosis Detection in Chest Radiographs: A Hybrid Deep Learning Framework for Clinical Decision Support

Applied AI Letters, Volume 7, Issue 2, June 2026.
A hybrid deep learning framework integrating VGG16, ResNet50, and DenseNet121 is proposed for automated tuberculosis detection from chest X‐ray images. Feature‐level fusion enhances robustness and generalization, achieving 97.4% accuracy across multiple public datasets, supporting reliable clinical decision‐making in resource‐limited healthcare ...
Md. Tahmid Hossain, Hrittik Mural, Monowar Wadud Hridoy   +2 more
wiley   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1845-1856, June 2026.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Contezolid in the Treatment of Multidrug‐Resistant Tuberculous Meningitis: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Multidrug‐resistant tuberculous meningitis (MDR‐TBM) has a high mortality rate, and treatment options are limited. Linezolid is recommended for refractory cases but often causes intolerable adverse reactions such as peripheral neuropathy. Contezolid, a novel oxazolidinone, has shown better safety profiles in preclinical and early clinical ...
Na Wang, Xingyu Li, Qiaoyi Yan, Haitao Su, Yufeng Liu, Yanhong Li, Chunrong Yang, Yingchun Gu, Taoli Yan, Qiuzhen Wang, Xia Liu   +10 more
wiley   +1 more source

Is HIV infection a risk factor for multi-drug resistant tuberculosis? A systematic review.

PLoS ONE, 2009
BackgroundTuberculosis (TB) is an important cause of human suffering and death. Human immunodeficiency virus (HIV), multi-drug resistant TB (MDR-TB), and extensive drug resistant tuberculosis (XDR-TB) have emerged as threats to TB control.
Sujit Suchindran, Emily S Brouwer, Annelies Van Rie   +2 more
doaj   +1 more source

High prevalence of primary multidrug resistant tuberculosis in persons with no known risk factors.

PLoS ONE, 2011
IntroductionIn high multidrug resistant (MDR) tuberculosis (TB) prevalence areas, drug susceptibility testing (DST) at diagnosis is recommended for patients with risk factors for MDR.
Larissa Otero, Fiorella Krapp, Cristina Tomatis, Carlos Zamudio, Francine Matthys, Eduardo Gotuzzo, Patrick Van der Stuyft, Carlos Seas   +7 more
doaj   +1 more source

Mitigating treatment failure of pulmonary pre-extensively drug-resistant tuberculosis: The role of new and repurposed drugs

Journal of Microbiology, Immunology and Infection
Background: Pre-extensively drug-resistant tuberculosis (pre-XDR-TB), defined as multidrug-resistant TB (MDR-TB) with additional resistance to any fluoroquinolone (FQ) is difficult to treat.
Yi-Wen Huang, Ming-Chih Yu, Chih-Bin Lin, Jen-Jyh Lee, Chou-Jui Lin, Shun-Tien Chien, Chih-Hsin Lee, Chen-Yuan Chiang   +7 more
doaj   +1 more source

Clinical Profiles of Multidrug-Resistant and Rifampicin-Monoresistant Tuberculosis in Korea, 2018–2021: A Nationwide Cross-Sectional Study [PDF]

Tuberculosis and Respiratory Diseases
Background This study aimed to identify the clinical characteristics of multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) in the Republic of Korea. Methods Data of notified people with tuberculosis between July 2018 and December 2021 were
Jinsoo Min, Yousang Ko, Hyung Woo Kim, Hyeon-Kyoung Koo, Jee Youn Oh, Doosoo Jeon, Taehoon Lee, Young-Chul Kim, Sung Chul Lim, Sung Soon Lee, Jae Seuk Park, Ju Sang Kim   +11 more
doaj   +1 more source

Yield of facility-based verbal screening amongst household contacts of patients with multi-drug resistant tuberculosis in Pakistan

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2017
Background: Household contacts of multidrug-resistant tuberculosis (MDR-TB) patients are at a high risk of getting infected with TB/MDR-TB, therefore symptomatic or vulnerable individuals should be screened and treated early.
Ejaz Qadeer, Razia Fatima, Mahboob Ul Haq, Aashifa Yaqoob, Nang Thu Thu Kyaw, Safieh Shah, Mrinalini Das, Petros Isaakidis   +7 more
doaj   +1 more source

Multidrug-resistant tuberculosis and risk factors associated with its development: a retrospective study

Journal of Infection in Developing Countries, 2015
Introduction: Multidrug-resistant tuberculosis (MDR-TB) has emerged as a major clinical public health threat and challenges the national TB control program in Malaysia. Data that elaborates on the risk factors associated with the development of MDR-TB is
Omar Sald Elmi, Habsah Hasan, Sarimah Abdullah, Mat Zuki Mat Jeab, Zilfalil Bin Alwi, Nyi Nyi Naing   +5 more
doaj   +1 more source