Results 111 to 120 of about 1,592,361 (298)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

TOPICS-MDS NPO care receiver-caregiver dyads

The Older Persons and Informal Caregivers Survey - Minimum DataSet (TOPICS-MDS) is a public data repository which contains information on the physical and mental health and well-being of older persons and informal caregivers and their care use across the
Olde Rikkert, M.G.M.
core   +1 more source

A characterization for an almost MDS code to be a near MDS code and a proof of the Geng-Yang-Zhang-Zhou conjecture [PDF]

Let $\mathbb{F}_q$ be the finite field of $q$ elements, where $q=p^{m}$ with $p$ being a prime number and $m$ being a positive integer. Let $\mathcal{C}_{(q, n, δ, h)}$ be a class of BCH codes of length $n$ and designed $δ$.
Wei, Huakai, Qiang, Shiyuan, Hong, Shaofang   +2 more
core   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Generalized GM-MDS: Polynomial Codes are Higher Order MDS [PDF]

The GM-MDS theorem, conjectured by Dau-Song-Dong-Yuen and proved by Lovett and Yildiz-Hassibi, shows that the generator matrices of Reed-Solomon codes can attain every possible configuration of zeros for an MDS code.
Brakensiek, Joshua, Dhar, Manik, Gopi, Sivakanth   +2 more
core   +3 more sources

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

X-Code: MDS Array Codes with Optimal Encoding [PDF]

, 1999
We present a new class of MDS array codes of size n \Theta n (n a prime number) called X-Code. The X-Codes are of minimum column distance 3, namely, they can correct either one column error or two column erasures. The key novelty in X-code is that it has
Bruck, Jehoshua, Xu, Lihao, Jehoshua Bruck, Lihao Xu   +3 more
core  

Plasma-MDS and DCAT metadata records for INPTDAT nodes 43 and 98

, 2020
This dataset contains the the JSON representation of Plasma-MDS version 0.9.1 as well as archival copies of the Plasma-MDS and DCAT metadata records for the datasets "Correlation of helicality and rotation frequency of filaments in the ntAPPJ" (node 43 ...
Becker, Markus M.
core   +1 more source