Results 1 to 10 of about 37,729 (256)

Muscular weakness in the mdx mouse

Journal of the Neurological Sciences, 1993
mdx mice are believed to be virtually free from neuromuscular symptoms, despite the presence of a degenerative/regenerative process that involves all skeletal muscles. We analyzed both the spontaneous motility and treadmill motor activity of mdx mice aged 15 days to 6 months.
Muntoni F., Mateddu A., Marchei F., Clerk A., SERRA, Gino   +4 more
openaire   +3 more sources

Neuromuscular transmission in the mdx mouse

Muscle & Nerve, 1990
AbstractThe mdx mouse is an animal model for human Duchenne dystrophy. In both disorders, the muscle fiber plasma membrane is rendered selectively vulnerable by dystrophin deficiency. In both disorders there are also ultrastructural abnormalities involving the postsynaptic membrane of the neuromuscular junction.
Alexandre Nagel, Andrew G. Engel, Frank Lehmann-Horn   +2 more
openaire   +3 more sources

Posttetanic potentiation in mdx muscle

Journal of Muscle Research and Cell Motility, 2010
X-linked muscular dystrophy of the mouse (mdx) has been reported to progressively remodel skeletal muscle to preferentially reduce fast fiber composition. Despite this, mdx muscle displays normal levels of posttetanic potentiation (PTP). Since PTP may primarily depend on phosphorylation of the myosin regulatory light chain (RLC) in fast muscle fibers ...
Rene Vandenboom, Ian Curtis Smith, A. R. Tupling, Jian Huang, Joe Quadrilatero   +4 more
openaire   +3 more sources

Dystrophin in control and mdx retina

Brain and Development, 1991
To determine whether or not dystrophin really exists in the outer plexiform layer (OPL) of the retina, we studied control and mdx mice, using four kinds of polyclonal antibodies (DMDP-II, 60 kd, 30 kd and DMDP-IV) against dystrophin. Although control OPL showed a positive immunohistochemical reaction with all four antibodies, mdx OPL showed a positive ...
Makoto Uchino, Teruhisa Miike, Masahiko Miyatake, Kowashi Yoshioka, Ji-en Zhao   +4 more
openaire   +3 more sources

Introduction to MDX

2011
In this chapter, you’ll work with Multidimensional Expressions (MDX), which is the native query language for SQL Server Analysis Services (SSAS). MDX is a SQL-like language used to query SSAS cubes.
Lynn Langit, Guy Fouché
openaire   +2 more sources

Genetically dystrophic mdx/mdx mice exhibit decreased response to nicotine in passive avoidance

Neuroreport, 2002
mdx mice are considered as a genetic homologous of human Duchenne muscular dystrophy. Recent evidence demonstrates that in mouse sympathetic ganglion dystrophin is involved in the stabilization of nicotinic acetylcholine receptor clusters. The purpose of this study was to verify possible effects of dystrophin alterations at the central level.
Roberto Coccurello, Claudio Castellano, PAGGI, Paola, MELE, Andrea, OLIVERIO, Alberto   +4 more
openaire   +5 more sources

Recursion in MDX

2002
The term ‘recursion’ is used to describe something that references itself. My favorite definition of recursion is found in the joke.
Robert Zare, Mark Whitehorn, Mosha Pasumansky   +2 more
openaire   +2 more sources

Running endurance abnormality in mdx mice

Muscle & Nerve, 2002
AbstractThe mdx mouse lacks dystrophin and has histological features of Duchenne muscular dystrophy but little weakness in the first year of life. We report here an early deficit in voluntary wheel running, as assayed with a computerized wheel. All mdx mice showed an intermittent running pattern, in contrast to the continuous running seen in controls ...
Kenneth H. Fischbeck, Patrick M. Nolan, Hajime Hara, Maja Bucan, Yoshihiro Wakayama, Marion O. Scott   +5 more
openaire   +3 more sources

Dystrophin distribution in heterozygote mdx mice

Muscle & Nerve, 1989
AbstractThe distribution of dystrophin in myofibers from normal, mdx hemizygous, and mdx heterozygous mice was studied at various times in development. While normal mice exhibit dystrophin immunostaining around the entire fiber periphery regardless of age, mdx hemizygous mice exhibit no staining (0–35 days). In contrast, young (10 day) heterozygous mdx
Louis M. Kunkel, Simon C. Watkins, Eric P. Hoffman, Henry S. Slayter   +3 more
openaire   +3 more sources

Normal Cochlear Function in mdx and mdx^Cv3 Duchenne Muscular Dystrophy Mouse Models [PDF]

The Laryngoscope, 1999
AbstractObjectives/Hypothesis: Sensorineural hearing loss has been found in association with inherited muscular dystrophies in humans and in mouse models. An increased brainstem auditory evoked response threshold has been previously reported in the dystrophin‐deficient mdx mouse model for Duchenne muscular dystrophy, suggesting that full‐length ...
Nancy M. Duncan, Shannon J. Dwinnell, Dennis R. Trune, Sean M. Rash, De-Ann M. Pillers, J. Beth Kempton   +5 more
openaire   +2 more sources