Results 1 to 10 of about 37,928 (204)

Validation of an hplc method for the determination of 1,7-dihydroxy-2,3-methylenedioxyxanthone in extracts obtained from Polygala cyparissias A. St. Hil. & Moq. (Polygalaceae) and evaluation of the influence of its content on the gastroprotective activity

open access: yesQuímica Nova, 2014
Polygala cyparissias is a plant widespread in Southern Latin America. Recently, we demonstrated the gastroprotective activity of the extract, as well as for one of the isolated metabolites-1,7-dihydroxy-2,3-methylenedioxyxanthone (MDX).
Luiz Carlos Klein-Júnior   +3 more
doaj   +1 more source

Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways

open access: yesSkeletal Muscle, 2023
Background The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabilizes the sarcolemma during ...
Jackie L. McCourt   +11 more
doaj   +1 more source

Restoration of pharyngeal dilator muscle force in dystrophin-deficient (mdx) mice following co-treatment with neutralizing interleukin-6 receptor antibodies and urocortin-2 [PDF]

open access: yes, 2017
New Findings: What is the central question of this study? We previously reported impaired upper airway dilator muscle function in the mdx mouse model of Duchenne muscular dystrophy (DMD).
Brannock, Molly   +7 more
core   +1 more source

Growth Factors Do Not Improve Muscle Function in Young or Adult mdx Mice [PDF]

open access: gold, 2022
Tue L. Nielsen   +5 more
openalex   +1 more source

Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice

open access: yesSkeletal Muscle
Despite its notoriously mild phenotype, the dystrophin-deficient mdx mouse is the most common model of Duchenne muscular dystrophy (DMD). By mimicking a human DMD-associated metabolic comorbidity, hyperlipidemia, in mdx mice by inactivating the ...
Ram B. Khattri   +7 more
doaj   +1 more source

The unconditioned fear response in dystrophin-deficient mice is associated with adrenal and vascular function

open access: yesScientific Reports, 2023
Loss of function mutations in the gene encoding dystrophin elicits a hypersensitive fear response in mice and humans. In the dystrophin-deficient mdx mouse, this behaviour is partially protected by oestrogen, but the mechanistic basis for this protection
Angus Lindsay, Aaron P. Russell
doaj   +1 more source

Derived Koszul Duality and Involutions in the Algebraic K-Theory of Spaces

open access: yes, 2010
We interpret different constructions of the algebraic $K$-theory of spaces as an instance of derived Koszul (or bar) duality and also as an instance of Morita equivalence. We relate the interplay between these two descriptions to the homotopy involution.
Blumberg, Andrew J., Mandell, Michael A.
core   +1 more source

An Internal Observability Estimate for Stochastic Hyperbolic Equations [PDF]

open access: yes, 2016
This paper is addressed to establishing an internal observability estimate for some linear stochastic hyperbolic equations. The key is to establish a new global Carleman estimate for forward stochastic hyperbolic equations in the $L^2$-space.
Fu, Xiaoyu, Liu, Xu, Lu, Qi, Zhang, Xu
core   +2 more sources

Crohn's disease-associated adherent-invasive Escherichia coli adhesion is enhanced by exposure to the ubiquitous dietary polysaccharide maltodextrin. [PDF]

open access: yesPLoS ONE, 2012
Crohn's disease (CD) is associated with intestinal dysbiosis evidenced by an altered microbiome forming thick biofilms on the epithelium. Additionally, adherent-invasive E.
Kourtney P Nickerson, Christine McDonald
doaj   +1 more source

Design and fabrication of a low cost implantable bladder pressure monitor [PDF]

open access: yes, 2009
In the frame of the Flemish Community funded project Bioflex we developed and fabricated an implant for short term (< 7 days) bladder pressure monitoring, and diagnosis of incontinence.
Axisa, Fabrice   +8 more
core   +2 more sources

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