Results 111 to 120 of about 34,705 (216)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, Volume 22, Issue 16, 17 March 2026.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Genetic diagnosis as a tool for personalized treatment of Duchenne muscular dystrophy [PDF]

, 2016
Accurate definition of genetic mutations causing Duchenne muscular dystrophy (DMD) has always been relevant in order to provide genetic counseling to patients and families, and helps to establish the prognosis in the case where the distinction between ...
Bello, Luca, Pegoraro, Elena
core  

Framework for X‐ray mirror surface shape fitting

Journal of Synchrotron Radiation, Volume 33, Issue 2, Page 278-288, March 2026.
The closed‐form expressions for elliptic cylinders, hyperbolic cylinders, ellipsoids, hyperboloids, and diaboloids used for X‐ray mirror surface shapes are summarized. Additionally, a four‐layer framework to fit the measured surface shape data in slope or height for convenient X‐ray mirror surface characterization is proposed.For accurate ...
Lei Huang, Ruochen Xu, Tianyi Wang, Jumpei Yamada, Joseph Dvorak, Corey Austin, Albert Van Eeckhout, Josep Nicolàs Roman, Kenneth Goldberg, Mourad Idir   +9 more
wiley   +1 more source

The beneficial effect of chronic muscular exercise on muscle fragility is increased by Prox1 gene transfer in dystrophic mdx muscle

PLoS ONE, 2022
Purpose Greater muscle fragility is thought to cause the exhaustion of the muscle stem cells during successive degeneration/repair cycles, leading to muscle wasting and weakness in Duchenne muscular dystrophy.
Alexandra Monceau, Clément Delacroix, Mégane Lemaitre, Gaelle Revet, Denis Furling, Onnik Agbulut, Arnaud Klein, Arnaud Ferry   +7 more
doaj  

Viscoelastic properties of dystrophin‐deficient mouse skeletal muscles are resilient to isometric fatiguing exercise

Physiological Reports, Volume 14, Issue 6, March 2026.
Abstract Exercise prescription for Duchenne muscular dystrophy (DMD) is complicated by the susceptibility of unstable skeletal muscle to contraction‐induced damage. Although evidence suggests that isometric contractions can confer molecular and physiological benefits to DMD muscle, their impact on viscoelastic properties has not been assessed in vivo ...
Deirdre L. Merry, Pavithran Devananthan, Natalia Kabaliuk, Angus Lindsay   +3 more
wiley   +1 more source

Senescent‐Like Myofibers Contribute to Anti‐Regenerative Cytokine Signaling in Duchenne Muscular Dystrophy

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
p16 expression in DMD model rats induces a senescent‐like state in myofibers accompanied by p16 and cytokine gene expression, reshaping systemic humoral environments. This cytokine‐rich milieu suppresses skeletal muscle regeneration, as demonstrated by impaired regeneration of transplanted wild‐type muscle.
Masanari Ikeda, Yukie Tanaka, Hidetoshi Sugihara, Takashi Matsuwaki, Keitaro Yamanouchi   +4 more
wiley   +1 more source

CD47 Promotes, While Exposure to Apoptotic Cells Destroys the Fusion Program of Differentiating Myoblasts

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
(A) CD47, acting in a cis‐manner with integrins, promotes myoblast fusion. TSP‐1 serves as a bridging molecule for these proteins to recognize PS on the surface of the other fusing myoblasts. (B) Blocking of these signals by neutralizing antibodies reduces cell fusion. Inhibition of PIEZO1 activity by constantly expressed PS on apoptotic cells leads to
Maysaa Adil Ali, Albert Bálint Papp, Éva Garabuczi, Áron Károly Gere, Beatrix Dienes, Mónika Gönczi, György Vámosi, Krisztina Köröskényi, László Csernoch, Zsuzsa Szondy, Zsolt Sarang   +10 more
wiley   +1 more source

Should Induction Chemotherapy Be Considered First‐Line Therapy for Sinonasal Undifferentiated Carcinoma?

The Laryngoscope, Volume 136, Issue 3, Page 1047-1049, March 2026.
Daniel X. Ma, Shirley Y. Su, Bobby A. Tajudeen, Edward C. Kuan   +3 more
wiley   +1 more source

Exploring the respiratory efficacy of combined chronic glucocorticoid and antioxidant interventions in the mdx mouse: The PREDNAC trial

Experimental Physiology
Duchenne muscular dystrophy (DMD) is characterized by respiratory muscle injury and weakness, ultimately leading to respiratory failure. Impaired respiratory muscle performance, fibrosis and inflammation in early disease are evident in the dystrophin ...
Michael N. Maxwell, Ben T. Murphy, Fiona B. McDonald, Ken D. O'Halloran   +3 more
doaj   +1 more source

Replacing Part of Maltodextrin with Galactose in Early Life Diet Results in an Improved Body Composition and Energy Metabolism in a Mouse Model

Proceedings
Background: Lactose, a disaccharide of glucose and galactose, is the primary carbohydrate found in milk. Recently, there has been an increased demand for low lactose/lactose-free infant formulas.
Maryam Rakhshandehroo, Peixin Sun, Melissa Bekkenkamp-Grovenstein, Lidewij Schipper, Evert M. Van Schothorst   +4 more
doaj   +1 more source