Results 21 to 30 of about 38,496 (259)

Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy. [PDF]

PLoS ONE, 2015
Various therapeutic approaches have been studied for the treatment of Duchenne muscular dystrophy (DMD), but none of these approaches have led to significant long-term effects in patients.
Kelly M Gutpell, William T Hrinivich, Lisa M Hoffman   +2 more
doaj   +1 more source

Sequencing protocols to genotype mdx, mdx^4cv, and mdx^5cv mice [PDF]

Muscle & Nerve, 2010
AbstractCurrently available polymerase chain reaction (PCR) genotyping methods for point mutations in the mouse dystrophin gene can lead to false positives and result in wasted time and money due to breeding or treating the wrong mice. Here we describe a simple and accurate method for sequencing the point mutations in mdx, mdx4cv, and mdx5cv mice. This
Glen B, Banks, Ariana C, Combs, Jeffrey S, Chamberlain   +2 more
openaire   +2 more sources

Two-dimensional speckle tracking echocardiography demonstrates improved myocardial function after intravenous infusion of bone marrow mesenchymal stem in the X-Linked muscular dystrophy mice

BMC Cardiovascular Disorders, 2022
Background Bone marrow mesenchymal stem cells (BMSCs) are commonly used in regenerative medicine. However, it is not clear whether transplantation of BMSCs can improve cardiac function of the X-Linked Muscular Dystrophy Mice (mdx) and how to detect it ...
Xiao Liu, Shixiang Yao, Min Pan, Yingying Cai, Weihui Shentu, Wenqian Cai, Hongkui Yu   +6 more
doaj   +1 more source

Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse. [PDF]

PLoS ONE, 2010
Thymosin beta-4 (Tbeta4) is a ubiquitous protein with many properties relating to cell proliferation and differentiation that promotes wound healing and modulates inflammatory mediators.
Christopher F Spurney, Hee-Jae Cha, Arpana Sali, Gouri S Pandey, Emidio Pistilli, Alfredo D Guerron, Heather Gordish-Dressman, Eric P Hoffman, Kanneboyina Nagaraju   +8 more
doaj   +1 more source

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment [PDF]

, 2018
Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive muscle weakness and premature death due to respiratory and/or cardiac complications.
Ball, V, Betts, C A, Gait, M J, Godfrey, C, Hammond, S M, Healicon, R, Manzano, R, McClorey, G, Merritt, T M, Muses, S, O'Donovan, L, Tyler, D, Wells, D J, Wells, K E, Westering, T, Wood, M J   +15 more
core   +3 more sources

Superpulsed low-level laser therapy protects skeletal muscle of mdx mice against damage, inflammation and morphological changes delaying dystrophy progression. [PDF]

, 2014
Aim: To evaluate the effects of preventive treatment with low-level laser therapy (LLLT) on progression of dystrophy in mdx mice. Methods: Ten animals were randomly divided into 2 experimental groups treated with superpulsed LLLT (904 nm, 15 mW, 700 Hz ...
A Gur, A Stergioulas, AP Gautam, B Hegedus, BJ Barber, CF Rizzi, CR Hayworth, D Avni, DE Lebel, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, Ernesto Cesar Pinto Leal-Junior, F Aimbire, F Aimbire, F Serra, GD Thomas, GF Cox, JA Goldman, Jan Magnus Bjordal, JK McGeachie, JM Bjordal, Jon Joensen, JR Basford, JS Chamberlain, KS Ramaswamy, Lucio Frigo, M Koenig, M Li, M Tullberg, Mark I. Johnson, Maurilio Sampaolesi, MM Schubert, O Ozcelik, P de Almeida, P de Almeida, Patrícia de Almeida, Paulo de Tarso Camillo de Carvalho, PC Silveira, R Albertini, R Albertini, RJ Fairclough, Rodrigo Álvaro Brandão Lopes-Martins, RT Chow, RT Chow, S Rao, S Rochkind, Shaiane Silva Tomazoni, T De Marchi, T Takema, TA Partridge, V Ricotti, W Lim, X Xu, Y Lampl, Y Moriyama, YY Huang   +60 more
core   +7 more sources

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic [PDF]

, 2018
A new line of dystrophic mdx mice on the DBA/2J (D2) background has emerged as a candidate to study the efficacy of therapeutic approaches for Duchenne muscular dystrophy (DMD). These mice harbor genetic polymorphisms that appear to increase the severity
Aartsma-Rus, A., Bogdanik, L, Davies, K, De Luca, A, Demonbruen, Ar, Duan, D, Elsey, D, Fukada, Si, Girgenrath, M, Gonzalez, Jp, Gordish-Dressman, H, Grounds, Md, Heydemann, A, Kreibich, A, Lutz, C, Nagaraju, K, Nichols, A, Partridge, T, Passini, M, Pazze, Ld, Sanarica, F, Schnell, Fj, Spencer, M, Spurney, C, van Putten, M, Wells, Dj, Willmann, R, Yokota, T, Young, Cs, Zhong, Z   +29 more
core   +3 more sources

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice [PDF]

, 2015
Duchenne muscular dystrophy (DMD) is characterized by progressive lethal muscle degeneration and chronic inflammatory response. The mdx mouse strain has served as the animal model for human DMD. However, while DMD patients undergo extensive necrosis, the
Berardinelli, Maria Grazia, Camilli, Carlotta, Catizone, Angela, De Benedetti, Fabrizio, Forcina, Laura, Musarò, Antonio, Nicoletti, Carmine, Pelosi, Laura, Rizzuto, Emanuele, Spelta, Elisa, Testa, Erika   +10 more
core   +2 more sources

Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype. [PDF]

, 2016
In the degenerative disease Duchenne muscular dystrophy, inflammatory cells enter muscles in response to repetitive muscle damage. Immune factors are required for muscle regeneration, but chronic inflammation creates a profibrotic milieu that exacerbates
Barton, Elisabeth R, Capote, Joana, Kramerova, Irina, Martinez, Leonel, Miceli, M Carrie, Spencer, Melissa J, Sweeney, H Lee, Vetrone, Sylvia   +7 more
core   +2 more sources

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]

, 2013
Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core   +3 more sources