Results 71 to 80 of about 37,729 (256)

Nifedipine treatment reduces resting calcium concentration, oxidative and apoptotic gene expression, and improves muscle function in dystrophic mdx mice. [PDF]

PLoS ONE, 2013
Duchenne Muscular Dystrophy (DMD) is a recessive X-linked genetic disease, caused by mutations in the gene encoding dystrophin. DMD is characterized in humans and in mdx mice by a severe and progressive destruction of muscle fibers, inflammation ...
Francisco Altamirano, Denisse Valladares, Carlos Henríquez-Olguín, Mariana Casas, Jose R López, Paul D Allen, Enrique Jaimovich   +6 more
doaj   +1 more source

Half‐Calcium Substitution of the CaB6 Surface with Hydrogen: Synthesis, Structural Characterization, and Electronic Structure

Small Structures, EarlyView.
A hydrogen boride component is formed on the calcium hexaboride (CaB6) surface via ion exchange. Protons replace approximately half the calcium in CaB6, forming three‐center two‐electron BHB bonds. The resulting HCa0.5B6 has alternating Ca‐rich and Ca‐deficient planes.
Hikari Yoshioka, Mitsuhiro Saito, Satoshi Tominaka, Susumu Okada, Mina Maruyama, Yanlin Gao, Ben Slater, Shin‐ichi Ito, Miwa Hikichi, Ryuki Tsuji, Osamu Oki, Yuichi Ikuhara, Shin‐ichi Orimo, Hideo Hosono, Takahiro Kondo   +14 more
wiley   +1 more source

Experimental investigations of synchrotron radiation at the onset of the quantum regime [PDF]

, 2012
The classical description of synchrotron radiation fails at large Lorentz factors, $\gamma$, for relativistic electrons crossing strong transverse magnetic fields $B$.
A. Dizdar, A. Mangiarotti, A. Sokolov, H. D. Thomsen, H. Knudsen, J. Esberg, J. S. Schwinger, K. K. Andersen, P. Sona, S. Ballestrero, T. J. Ketel, U. I. Uggerhøj, V. Baier, V. N. Baier, V. N. Baier   +14 more
core   +3 more sources

Altered muscle niche contributes to myogenic deficit in the D2-mdx model of severe DMD

Cell Death Discovery, 2023
Lack of dystrophin expression is the underlying genetic basis for Duchenne muscular dystrophy (DMD). However, disease severity varies between patients, based on specific genetic modifiers. D2-mdx is a model for severe DMD that exhibits exacerbated muscle
Davi A. G. Mázala, Ravi Hindupur, Young Jae Moon, Fatima Shaikh, Iteoluwakishi H. Gamu, Dhruv Alladi, Georgiana Panci, Michèle Weiss-Gayet, Bénédicte Chazaud, Terence A. Partridge, James S. Novak, Jyoti K. Jaiswal   +11 more
doaj   +1 more source

Enhanced Hydrogen Release from Hydrogen Boride Nanosheets via Carbon Doping

Small Structures, EarlyView.
This study reports the synthesis of carbon‐doped hydrogen boride nanosheets through an ion‐exchange approach. Carbon incorporation weakens BHB bonds, enhancing hydrogen release under thermal and ultraviolet stimuli. Spectroscopic analysis and density functional theory calculations confirm the structural and electronic changes, demonstrating carbon ...
Riku Kawamura, Reiya Kawamura, Arpita Varadwaj, Kazuaki Kisu, Rika Tanaka, Akiyasu Yamamoto, Ryota Ishibiki, Shin‐ichi Ito, Takeshi Fujita, Tomoharu Tokunaga, Osamu Oki, Yoshitaka Fujimoto, Masayuki Toyoda, Susumu Saito, Toyoto Sato, Shin‐ichi Orimo, Hideo Hosono, Iwao Matsuda, Masato Kotsugi, Masahiro Miyauchi, Takahiro Kondo   +20 more
wiley   +1 more source

An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells. [PDF]

, 2013
Duchenne muscular dystrophy is a progressive and incurable neuromuscular disease caused by genetic and biochemical defects of the dystrophin-glycoprotein complex.
Borges, Luciene, Chamberlain, Jeffrey S, Darabi, Radbod, Ervasti, James M, Filareto, Antonio, Iacovino, Michelina, Kyba, Michael, Mayerhofer, Timothy, McIvor, R Scott, Parker, Sarah, Perlingeiro, Rita CR, Schaaf, Tory   +11 more
core   +2 more sources

Application of Fluorescence Two-Dimensional Difference In-Gel Electrophoresis as a Proteomic Biomarker Discovery Tool in Muscular Dystrophy Research

Biology, 2013
In this article, we illustrate the application of difference in-gel electrophoresis for the proteomic analysis of dystrophic skeletal muscle. The mdx diaphragm was used as a tissue model of dystrophinopathy.
Steven Carberry, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +3 more
doaj   +1 more source

DNA‐Methylation for Risk‐Stratification of Women Without a Fully Visible Transformation Zone at Colposcopy: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the performance of DNA methylation markers for the detection of cervical precancer among screening‐positive older women without a fully visible transformation zone at colposcopy (TZ3). Design Cross‐sectional study. Setting Colposcopy clinics, Central Denmark Region, 2019–2021.
Karen Omann Binderup, Joachim Boers, Line Winther Gustafson, Berit Andersen, Lone Kjeld Petersen, Pinar Bor, Joost Gribnau, Wim G. V. Quint, Henk Van Den Munckhof, Mette Tranberg, Anne Hammer   +10 more
wiley   +1 more source

Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy. [PDF]

, 2019
Many potentially therapeutic molecules have been identified for treating Duchenne muscular dystrophy. However, targeting those molecules only to sites of active pathology is an obstacle to their clinical use.
Bertoni, Carmen, Flores, Ivan, Ramos, Julian, Tidball, James G, Wang, Ying, Wehling-Henricks, Michelle, Welc, Steven S   +6 more
core  

An Internal Observability Estimate for Stochastic Hyperbolic Equations [PDF]

, 2016
This paper is addressed to establishing an internal observability estimate for some linear stochastic hyperbolic equations. The key is to establish a new global Carleman estimate for forward stochastic hyperbolic equations in the $L^2$-space.
Fu, Xiaoyu, Liu, Xu, Lu, Qi, Zhang, Xu
core   +2 more sources