Results 81 to 90 of about 37,928 (204)

Application of Fluorescence Two-Dimensional Difference In-Gel Electrophoresis as a Proteomic Biomarker Discovery Tool in Muscular Dystrophy Research

Biology, 2013
In this article, we illustrate the application of difference in-gel electrophoresis for the proteomic analysis of dystrophic skeletal muscle. The mdx diaphragm was used as a tissue model of dystrophinopathy.
Steven Carberry, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +3 more
doaj   +1 more source

Temporal Bayesian classifiers for modelling muscular dystrophy expression data [PDF]

, 2006
The analysis of microarray data from time-series experiments requires specialised algorithms, which take the temporal ordering of the data into account. In this paper we explore a new architecture of Bayesian classifier that can be used to understand how
Hoen, PAC't, Liu, X, Tucker, A, Vinciotti, V   +3 more
core  

Ergodic Mean Field Games with H\"ormander diffusions [PDF]

, 2017
We prove existence of solutions for a class of systems of subelliptic PDEs arising from Mean Field Game systems with H\"ormander diffusion. These results are motivated by the feedback synthesis Mean Field Game solutions and the Nash equilibria of a large
Dragoni, Federica, Feleqi, Ermal
core   +3 more sources

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

miR-146a deficiency does not aggravate muscular dystrophy in mdx mice

Skeletal Muscle, 2019
Duchenne muscular dystrophy (DMD) is a genetic disease evoked by a mutation in the dystrophin gene. It is associated with progressive muscle degeneration and increased inflammation.
Iwona Bronisz-Budzyńska, Katarzyna Chwalenia, Olga Mucha, Paulina Podkalicka, Karolina-Bukowska-Strakova, Alicja Józkowicz, Agnieszka Łoboda, Magdalena Kozakowska, Józef Dulak   +8 more
doaj   +1 more source

Genomic prostate score and treatment selection in favourable intermediate‐risk prostate cancer

BJUI Compass
Objective To assess the factors associated with the use of active surveillance (AS) in NCCN favourable intermediate‐risk (FIR) prostate cancer (PCa) patients who received the 17‐gene Genomic Prostate Score (GPS) assay.
Eric Margolis, Benjamin H. Lowentritt, Christopher M. Pieczonka, John P. Bennett, Marina Pavlova, Joao Paulo Zambon, Jack Groskopf, Edward Uchio   +7 more
doaj   +1 more source

Targeting CD70 in cancer: Mechanisms of immune escape and translational opportunities

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Hypoxia, oncogenic signaling (e.g., MAPK, STAT3), and histone modifications promote CD70 overexpression in cancer cells. Viral infections like EBV and HTLV‐1 induce CD70 expression in tumor and transformed immune cells. Tyrosine kinase inhibitors and chemotherapeutic agents induce CD70 expression through therapy‐related stress in cancer cells ...
Akash Sabarwal, Saba Tabasum, Laxminarayan Rawat, Soumitro Pal   +3 more
wiley   +1 more source

Cromolyn administration (to block mast cell degranulation) reduces necrosis of dystrophic muscle in mdx mice

Neurobiology of Disease, 2006
Duchenne muscular dystrophy is a lethal muscle wasting disorder, resulting from mutations in the gene encoding for the skeletal muscle protein dystrophin.
Hannah G. Radley, Miranda D. Grounds
doaj   +1 more source

Dose‐ and Duration‐Dependent Effects of Propylene Glycol on Lipid Metabolism‐Related mRNAs, Proteins, and Fatty Acids in the Adipose Tissue of Fattening Akkaraman Lambs

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Propylene glycol modulated lipid metabolism in gluteal fat tissue. Expression of FABP4 at Day 60 and 120, and PPARγ and C/EBPα at Day 120 were upregulated, while SREBP1c was downregulated at both the mRNA (Day 120) and protein levels (Day 60 and 120).
Akın Yakan, Hüseyin Özkan, Hasan Hüseyin Keçeli, Ufuk Kaya, Irem Karaaslan, Sevda Dalkiran, Necmettin Ünal, Baran Çamdeviren, Güven Güngör, Mehmet Küçükoflaz, Savaş Sariözkan, Korhan Arslan, Bilal Akyüz, Aytaç Akçay, Ceyhan Özbeyaz   +14 more
wiley   +1 more source

Fast Myosin Binding Protein‐C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Skeletal muscle plays a vital role in voluntary movement and locomotion. Fast‐twitch muscle fibres are characterized by their rapid contraction kinetics, high‐force generation and a distinct gene expression profile compared to slow‐twitch fibres.
Akhil Baby, Kalyani Ananthamohan, Brenna N. McIntyre, Sankar Natesan, Taejeong Song   +4 more
wiley   +1 more source