Results 81 to 90 of about 37,729 (256)
miR-146a deficiency does not aggravate muscular dystrophy in mdx mice
Skeletal Muscle, 2019 Duchenne muscular dystrophy (DMD) is a genetic disease evoked by a mutation in the dystrophin gene. It is associated with progressive muscle degeneration and increased inflammation.
Iwona Bronisz-Budzyńska +8 more
doaj +1 more source
Skeletal Muscle, 2023 Background The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabilizes the sarcolemma during ...
Jackie L. McCourt +11 more
doaj +1 more source
Cell Proliferation, EarlyView.CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far +4 more
wiley +1 more source
Prmt5 is a regulator of muscle stem cell expansion in adult mice. [PDF]
, 2015 Skeletal muscle stem cells (MuSC), also called satellite cells, are indispensable for maintenance and regeneration of adult skeletal muscles. Yet, a comprehensive picture of the regulatory events controlling the fate of MuSC is missing.
Braun, Thomas +7 more
core
¹³C NMR metabolomics: applications at natural abundance. [PDF]
, 2014 (13)C NMR has many advantages for a metabolomics study, including a large spectral dispersion, narrow singlets at natural abundance, and a direct measure of the backbone structures of metabolites.
Clendinen, Chaevien +7 more
core +3 more sources
Scientific Reports, 2023 Loss of function mutations in the gene encoding dystrophin elicits a hypersensitive fear response in mice and humans. In the dystrophin-deficient mdx mouse, this behaviour is partially protected by oestrogen, but the mechanistic basis for this protection
Angus Lindsay, Aaron P. Russell
doaj +1 more source
Combating muscle atrophy: emerging therapeutic targets that are fiber‐type‐specific
The FEBS Journal, EarlyView.Inflammation, denervation or decreased insulin signaling activate proteolysis and cause muscle wasting. Pathological conditions like obesity and DMD can also exacerbate atrophy via PGD2–RhoA–ROCK2 signaling. In contrast, exercise, dietary interventions, and pharmacological agents can activate Ca2+/calcineurin–NFAT and AMPK–PGC‐1α–MEF pathways ...
Samrat Chakraborty +2 more
wiley +1 more source
Neurobiology of Disease, 2006 Duchenne muscular dystrophy is a lethal muscle wasting disorder, resulting from mutations in the gene encoding for the skeletal muscle protein dystrophin.
Hannah G. Radley, Miranda D. Grounds
doaj +1 more source
Crohn's disease-associated adherent-invasive Escherichia coli adhesion is enhanced by exposure to the ubiquitous dietary polysaccharide maltodextrin. [PDF]
PLoS ONE, 2012 Crohn's disease (CD) is associated with intestinal dysbiosis evidenced by an altered microbiome forming thick biofilms on the epithelium. Additionally, adherent-invasive E.
Kourtney P Nickerson, Christine McDonald
doaj +1 more source
T-Cell-Dependent Fibrosis in the mdx Dystrophic Mouse [PDF]
Laboratory Investigation, 2000 In Duchenne muscular dystrophy patients, the pathological hallmark of the disease, namely, the chronic accumulation of sclerotic scar tissue in the interstitial space of skeletal muscle is attributed to manifestation of secondary pathological processes.
Morrison, J +4 more
openaire +3 more sources