Results 141 to 150 of about 19,576 (264)

Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy

Cell Death and Disease
Absence of dystrophin protein causes cardiac dysfunction in patients with Duchenne muscular dystrophy (DMD). Unlike boys with DMD, the common mouse model of DMD (B10-mdx) does not manifest cardiac deficits until late adulthood.
James S. Novak, Amy Lischin, Prech Uapinyoying, Ravi Hindupur, Young Jae Moon, Surajit Bhattacharya, Sarah Tiufekchiev-Grieco, Victoria Barone, Davi A. G. Mázala, Iteoluwakishi H. Gamu, Gabriela Walters, Jyoti K. Jaiswal   +11 more
doaj   +1 more source

Regulation of cytosolic calcium in skeletal muscle cells of the mdx mouse under conditions of stress [PDF]

, 1996
W. J. Leijendekker, Anne‐Catherine Passaquin, Laurent Metzinger, Urs T. Rüegg   +3 more
openalex   +1 more source

Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy [PDF]

, 2019
Tatiana M. Fontelonga, Brennan Jordan, Andreia M. Nunes, Pamela Barraza‐Flores, Nicholas C. Bolden, Ryan D. Wuebbles, Lesley A. Mathews Griner, Xin Hu, Marc Ferrer, Juan Marugán, Noel Southall, Dean J. Burkin   +11 more
openalex   +1 more source

Dystrophin Cytochemistry in Mdx Mouse Muscles Injected with Labeled Normal Myoblasts

Cell Transplantation, 1992
A new technique enables correlation of dystrophin expression with the location of donor versus host nuclei in the same sections of mdx mouse muscle injected with normal myoblasts. Myoblasts from C57BL/6J mice or from humans were labeled with 0.01% fluoro-
Ming Chen, Hua-Ju Li, Qiuwen Fang, Tena G. Goodwin, J. Ann Florendo, Peter K. Law   +5 more
doaj   +1 more source

Expression and function of four AAV-based constructs for dystrophin restoration in the mdx mouse model of Duchenne muscular dystrophy. [PDF]

Biol Open, 2023
Potter RA, Griffin DA, Heller KN, Mendell JR, Rodino-Klapac LR.   +4 more
europepmc   +1 more source

Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice [PDF]

, 2017
Aims Duchenne muscular dystrophy (DMD) is a severe striated muscle disease due to the absence of dystrophin. Dystrophin deficiency results in dysfunctional sodium channels and conduction abnormalities in hearts of mdx mice. Disease progression in the mdx
Abriel, Hugues, Albesa, Maxime, Ogrodnik, Jakob, Rougier, Jean-Sébastien   +3 more
core  

Humanization of the mdx Mouse Phenotype for Duchenne Muscular Dystrophy Modeling: A Metabolic Perspective. [PDF]

J Neuromuscul Dis, 2023
Donen G, Milad N, Bernatchez P.
europepmc   +1 more source

QuantiMus: A Machine Learning-Based Approach for High Precision Analysis of Skeletal Muscle Morphology. [PDF]

, 2019
Skeletal muscle injury provokes a regenerative response, characterized by the de novo generation of myofibers that are distinguished by central nucleation and re-expression of developmentally restricted genes.
Ayer, Rachel E, Ellefsen, Kyle L, Giebel, Jesse J, Kastenschmidt, Jenna M, Mannaa, Ali H, Mozaffar, Tahseen, Pham, Phillip, Rios, Rodolfo, Vetrone, Sylvia A, Villalta, S Armando, Yahia, Rayan   +10 more
core   +2 more sources

Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice

Skeletal Muscle
Despite its notoriously mild phenotype, the dystrophin-deficient mdx mouse is the most common model of Duchenne muscular dystrophy (DMD). By mimicking a human DMD-associated metabolic comorbidity, hyperlipidemia, in mdx mice by inactivating the ...
Ram B. Khattri, Abhinandan Batra, Zoe White, David Hammers, Terence E. Ryan, Elisabeth R. Barton, Pascal Bernatchez, Glenn A. Walter   +7 more
doaj   +1 more source

Memory impairment in the D2.mdx mouse model of Duchenne muscular dystrophy is prevented by the adiponectin receptor agonist ALY688. [PDF]

Exp Physiol, 2023
Bellissimo CA, Castellani LN, Finch MS, Murugathasan M, Gandhi S, Sweeney G, Abdul-Sater AA, MacPherson REK, Perry CGR.   +8 more
europepmc   +1 more source