Results 51 to 60 of about 213,848 (240)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Forecasting Ukraine’s Macroeconomic Development in Conditions of Uncertainty: Expectations and Reality

Статистика України
. The evaluation of forecast accuracy is one of the key instruments for assessing the reliability and practical value of analytical models applied by various institutions in the field of macroeconomic forecasting.
L. O. Yashchenko, O. P. Zhak, R. S. Lysenko, M. O. Rudenko   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

What the mean absolute percentage error (MAPE) should adopt from Bland–Altman analyses

German Journal of Exercise and Sport Research
Abstract Reporting reliability with precision and accuracy is of paramount importance in empirical data collections to ascertain whether data is trustworthy. Reliability is often quantified using the intraclass correlation coefficient (ICC), from which the standard error of measurement (SEM) and the minimal detectable change (MDC) can
Konstantin Warneke, Stanislav D. Siegel, José Afonso, Sebastian Wallot   +3 more
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Modeling of the output current of a photovoltaic grid-connected system using random forests technique

Energy Exploration & Exploitation, 2018
This study presents a prediction technique for the output current of a photovoltaic grid-connected system by using random forests technique. Experimental data of a photovoltaic grid-connected system are used to train and validate the proposed model ...
Ibrahim A Ibrahim, Tamer Khatib, Azah Mohamed, Wilfried Elmenreich   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Soil Temperature and Moisture Forecasting Using Exponential Smoothing Method Based on Mean Absolute Percentage Error

Indonesian Journal of Applied Informatics
Soil is an essential medium for almost all plants. Temperature and moisture in the soil become one of the factors that affect plant growth. Unbalanced or unfavorable soil conditions will adversely affect the plant. Therefore, soil conditions, including temperature and moisture, must be monitored to maintain plant health. Forecasting can be used to find
Muhamad Nur Azmi Wahyudi, Cucuk Wawan Budiyanto, Mohd. Shafie Bin Bakar   +2 more
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Trend equation prediction in medical and pharmaceutical studies (the example of respiratory diseases development in children in the region)

Сеченовский вестник, 2017
The article discusses the incidence forecast on the example of respiratory diseases in children in Nizhny Novgorod. The study used the official statistics of the respiratory diseases prevalence in children of 0-14 age group in 2001-2015.
O. V. Zhukova, S. V. Kononova, T. M. Konyshkina   +2 more
doaj