Results 101 to 110 of about 5,561,344 (365)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

A new type of canal surface in Euclidean 4-space E^4

open access: yesSakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2019
Bu çalışmada, E^4 4-boyutlu Öklid uzayında, merkez eğrisinin paralel öteleme çatısı vektörleri yardımıyla tanımlanan kanal yüzeyini örneği ile verdik.
Günay Öztürk   +2 more
doaj   +1 more source

On stable constant mean curvature surfaces with free boundary [PDF]

open access: yes, 2016
Ros and Vergasta (Geom Dedicata 56:19–33, 1995) proved, among others interesting results, a theorem which states that an immersed orientable compact stable constant mean curvature surface $$\Sigma $$Σ with free boundary in a closed ball $$B\subset ...
Ivaldo Nunes
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Neckpinch singularities in fractional mean curvature flows [PDF]

open access: yes, 2016
In this paper we consider the evolution of boundaries of sets by a fractional mean curvature flow. We show that for any dimension n >= 2, there exist embedded hypersurfaces in Rn which develop a singularity without shrinking to a point. Such examples are
E. Cinti, C. Sinestrari, E. Valdinoci
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Singular surfaces of revolution with prescribed unbounded mean curvature

open access: yesAnais da Academia Brasileira de Ciências
: We give an explicit formula for singular surfaces of revolution with prescribed unbounded mean curvature. Using this mean curvature, we give conditions for certain types of singularities of those surfaces. Periodicity of that surface is also discussed.
MARTINS LUCIANA F.   +3 more
doaj   +1 more source

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