Results 91 to 100 of about 255,201 (317)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Uniform flow distribution to stacked parallel disk channels in a disk shape small-capacity SOFC stack model

Nihon Kikai Gakkai ronbunshu, 2020
The design of a flow distribution to multiple branch channels is one of the key factors to realize the flow uniformity in a fuel cell stack. Especially for a disk-shape solid oxide fuel cell (SOFC) stack, it is necessary to clarify the optimum structure ...
Kazumi TSUNODA, Koichi TAKEYAMA, Tsuyoshi OISHI   +2 more
doaj   +1 more source

The mean curvature flow on solvmanifolds

Boletín de la Sociedad Matemática Mexicana
This work is a survey of the most relevant background material to motivate and understand the construction and classification of translating solutions to mean curvature flow on a family of solvmanifolds. We introduce the mean curvature flow and some known results in the field.
Romina M. Arroyo, Gabriela P. Ovando, Raquel Perales, Mariel Sáez   +3 more
openaire   +2 more sources

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Uniform Gaussian Bounds for Subelliptic Heat Kernels and an Application to the Total Variation Flow of Graphs over Carnot Groups

Analysis and Geometry in Metric Spaces, 2013
In this paper we study heat kernels associated with a Carnot group G, endowed with a family of collapsing left-invariant Riemannian metrics σε which converge in the Gromov- Hausdorff sense to a sub-Riemannian structure on G as ε→ 0.
Capogna Luca, Citti Giovanna, Manfredini Maria   +2 more
doaj   +1 more source

Mean Curvature Flow with Boundary

, 2019
We develop a theory of surfaces with boundary moving by mean curvature flow. In particular, we prove a general existence theorem by elliptic regularization, and we prove boundary regularity at all positive times under very mild hypotheses.
openaire   +3 more sources

Starshaped hypersurfaces and the mean curvature flow

Manuscripta Mathematica, 1998
The author generalizes a result of \textit{G. Huisken} and \textit{C. Sinestrari} [`Mean curvature flow singularities for mean convex surfaces', Calc. Var. Partial Differ. Equ. 8, No.1, 1-14 (1999)], giving conditions such that under the mean curvature flow a type II singularity develops. Whereas Huisken-Sinestrari's paper gets the result assuming that
openaire   +3 more sources

Harnack estimate for the mean curvature flow [PDF]

Journal of Differential Geometry, 1995
The author derives a differential Harnack inequality for weakly convex solutions of the mean curvature flow. This flow is the evolution of a hypersurface \(M^n\) in Euclidean space \(\mathbb{R}^{n + 1}\) by its mean curvature. As an application he shows that any strictly convex solution of the flow which is defined for all times and such that the mean ...
openaire   +4 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source