Results 91 to 100 of about 265,786 (329)

Modelling Free Flow Speed on Two-Lane Rural Highways in Bosnia and Herzegovina

Promet (Zagreb), 2014
Free flow speed is used as a parameter in transportation planning and capacity analysis models, as well as speed-flow diagrams. Many of these models suggest estimating free flow speed according to measurements from similar highways, which is not a ...
Ivan Lovrić, Dražen Cvitanić, Deana Breški   +2 more
doaj   +1 more source

Uniform flow distribution to stacked parallel disk channels in a disk shape small-capacity SOFC stack model

Nihon Kikai Gakkai ronbunshu, 2020
The design of a flow distribution to multiple branch channels is one of the key factors to realize the flow uniformity in a fuel cell stack. Especially for a disk-shape solid oxide fuel cell (SOFC) stack, it is necessary to clarify the optimum structure ...
Kazumi TSUNODA, Koichi TAKEYAMA, Tsuyoshi OISHI   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Mean curvature blow up in mean curvature flow

, 2009
In this note we establish that finite-time singularities of the mean curvature flow of compact Riemannian submanifolds are characterised by the blow up of the mean curvature.
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Uniform Gaussian Bounds for Subelliptic Heat Kernels and an Application to the Total Variation Flow of Graphs over Carnot Groups

Analysis and Geometry in Metric Spaces, 2013
In this paper we study heat kernels associated with a Carnot group G, endowed with a family of collapsing left-invariant Riemannian metrics σε which converge in the Gromov- Hausdorff sense to a sub-Riemannian structure on G as ε→ 0.
Capogna Luca, Citti Giovanna, Manfredini Maria   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Sharp upper bounds for the capacity in the hyperbolic and Euclidean spaces

Advances in Nonlinear Analysis
We derive various sharp upper bounds for the pp-capacity of a smooth compact set KK in the hyperbolic space Hn{{\mathbb{H}}}^{n} and the Euclidean space Rn{{\mathbb{R}}}^{n}.
Li Haizhong, Li Ruixuan, Xiong Changwei
doaj   +1 more source

Role of curvature in controlling SWBLI behavior in a hypersonic double ramp flow

Frontiers in Mechanical Engineering
Hypersonic flows generate intense unsteady pressure and thermal loads, posing significant challenges for high-speed aerospace applications such as re-entry vehicles and hypersonic cruise systems.
Abhinav Aggarwal, Rajesh Ranjan
doaj   +1 more source