Results 131 to 140 of about 872,045 (323)

The preservability of the curvature-adaptedness along the mean curvature flow [PDF]

open access: yesarXiv, 2020
In this paper, we investigate the preservability of the curvature-adaptedness along the mean curvature flow starting from a compact curvature-adapted hypersurface in locally symmetric spaces, where the curvature-adaptedness means that the shape operator and the normal Jacobi operator of the hypersurface commute.
arxiv  

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Investigating the effect of buried walls through rockfill detention structures on the longitudinal water surface profile [PDF]

open access: yesJournal of Hydraulic Structures
Rockfill structures in river training projects, such as detention dams, gabions, and levees, play a significant role in flood control. One of the common types of these structures is porous flood mitigation dams.
Jafar Chabokpour, Omar Minaei
doaj   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Interface evolution of microdroplets in flow-focusing channels with varying aspect ratios

open access: yesFlow
This study combines experimental observations and numerical simulations to comprehensively analyse the interface evolution of confined droplets in microfluidic devices with flow-focusing junctions under different aspect ratios.
Luyao He   +3 more
doaj   +1 more source

Drag Reduction Effects of Micro-Bubbles in Straight and Helical Pipes

open access: yesJournal of Fluid Science and Technology, 2009
Experimental investigations were conducted to study the effect of micro-bubbles injected into water flowing through straight and helical pipes with different curvature ( 0.025, 0.05 and 0.1).
Mohammed M. E. SHATAT   +3 more
doaj   +1 more source

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