Results 81 to 90 of about 255,201 (317)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Mean curvature flow of spacelike graphs [PDF]
Mathematische Zeitschrift, 2010 version 5: Math.Z (online first 30 July 2010). version 4: 30 pages: we replace the condition $K_1\geq 0$ by the the weaker one $Ricci_1\geq 0$. The proofs are essentially the same. We change the title to a shorter one.
Guanghan Li +2 more
openaire +4 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Mean curvature flow of Reifenberg sets [PDF]
Geometry & Topology, 2017 In this paper, we prove short time existence and uniqueness of smooth evolution by mean curvature in $\mathbb{R}^{n+1}$ starting from any $n$-dimensional $(\varepsilon,R)$-Reifenberg flat set with $\varepsilon$ sufficiently small. More precisely, we show that the level set flow in such a situation is non-fattening and smooth.
openaire +4 more sources
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Advances in Nonlinear AnalysisOur purpose is to establish nonexistence results concerning complete noncompact mean curvature flow solitons with polynomial volume growth immersed in certain semi-Riemannian warped products, under mild constraints on the warping and soliton functions ...
Batista Márcio +3 more
doaj +1 more source
Modelling Free Flow Speed on Two-Lane Rural Highways in Bosnia and Herzegovina
Promet (Zagreb), 2014 Free flow speed is used as a parameter in transportation planning and capacity analysis models, as well as speed-flow diagrams. Many of these models suggest estimating free flow speed according to measurements from similar highways, which is not a ...
Ivan Lovrić +2 more
doaj +1 more source
Swampland, gradient flow and infinite distance
Journal of High Energy Physics, 2020 In the first part of this paper we will work out a close and so far not yet noticed correspondence between the swampland approach in quantum gravity and geometric flow equations in general relativity, most notably the Ricci flow.
Alex Kehagias +2 more
doaj +1 more source
Fattening in mean curvature flow
32 pages, 2 figures.
Ilmanen, Tom, White, Brian
openaire +2 more sources