Results 41 to 50 of about 51,887 (242)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Another Two-Parameter Sujatha Distribution with Properties and Applications

Journal of Mathematical Sciences and Modelling, 2019
In this paper another two-parameter Sujatha distribution (ATPSD), which includes exponential distribution and Sujatha distribution as particular cases, has been proposed.
Rama Shanker, Mussie Tesfay
doaj   +1 more source

Circadian rhythm and sleep alterations in older people with lifetime depression: a case-control study

BMC Psychiatry, 2020
Background Depression is common in older people and is associated with underlying brain change increasing the risk of dementia. Sleep disturbance is frequently reported by those with lifetime depression, however whether circadian misalignment also exists
Camilla M. Hoyos, Christopher Gordon, Zoe Terpening, Louisa Norrie, Simon J. G. Lewis, Ian B. Hickie, Sharon L. Naismith   +6 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A New Lifetime Distribution with Decreasing and Upside-Down Bathtub-Shaped Hazard Rate Function

Statistica, 2020
We introduce a new lifetime distribution, called the alpha-power transformed Lomax (APTL) distribution which generalizes the Lomax distribution to provide better fits than the Lomax distribution and some of its known generalizations.
Sanku Dey, Mazen Nassar, Devendra Kumar, Ayman Alzaatreh, Muhammad Hussain Tahir   +4 more
doaj   +1 more source

Harmonic Mixture Fréchet Distribution: Properties and Applications to Lifetime Data

International Journal of Mathematics and Mathematical Sciences, 2022
In this study, we propose a four-parameter probability distribution called the harmonic mixture Fréchet. Some useful expansions and statistical properties such as moments, incomplete moments, quantile functions, entropy, mean deviation, median deviation,
Selasi Kwaku Ocloo, Lewis Brew, Suleman Nasiru, Benjamin Odoi   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A new extension of inverse length biased exponential model with statistical inference under joint censored samples and application

Alexandria Engineering Journal
In this paper, we introduce a new two-parameter lifetime distribution based on the type II Topp-Leone-G family and the inverse length biased exponential distribution which is called the type II Topp-Leone inverse length biased exponential (TIITL-ILBE ...
Mahmoud M. Abdelwahab, Ibrahim Elbatal, Mohammed Elgarhy, Anis Ben Ghorbal, H.E. Semary, Ehab M. Almetwally   +5 more
doaj   +1 more source