Results 51 to 60 of about 671,541 (215)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Mean estimation using an efficient class of estimators based on simple random sampling: Simulation and applications

Alexandria Engineering Journal
In this article, we offer simple random sampling (SRS) based efficient class of estimators of population mean Y¯ utilizing additional information. The expression of the mean square error of the proposed class of estimators is deduced up to first degree ...
Anoop Kumar, Asra Sayeed Siddiqui, Manahil SidAhmed Mustafa, Eslam Hussam, Hassan M. Aljohani, Fatimah A. Almulhim   +5 more
doaj   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Two Nonparametric Estimators of the Mean Residual Life

Revstat Statistical Journal, 2013
The mean residual life function L(t) can be written based on the vitality function V (t). In this article we propose two methods to estimate V (t). The two methods are based on both the kernel density estimation and the empirical function.
Abdel-Razzaq Mugdadi , Amanuel Teweldemedhin   +1 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Quaternion Filtering Based on Quaternion Involutions and its Application in Signal Processing

IEEE Access, 2019
The quaternion gradient plays an important role in quaternion signal processing, and has undergone several modifications. Recently, three methods for obtaining the quaternion gradient have been proposed based on generalized HR calculus, the quaternion ...
Gang Wang, Rui Xue
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Nonlinear Distortion-Aware Channel Estimation Strategies for IRS-Aided MIMO Systems

IEEE Access
The article addresses the challenges posed by nonlinear distortions in Intelligent Reflecting Surface (IRS)-assisted Multiple-Input Multiple-Output (MIMO) systems, which are often overlooked in conventional channel estimation strategies.
D. L. Sharini, Ravilla Dilli, M. Kanthi, G. D. Goutham Simha   +3 more
doaj   +1 more source

Error propagation approach for estimating root mean square error of the reference evapotranspiration when estimated with alternative data

Journal of Agricultural Engineering, 2019
Estimation of reference evapotranspiration (ET0) with the Food and Agricultural Organisation (FAO) Penman-Monteith model requires temperature, relative humidity, solar radiation, and wind speed data.
Homayoon Ganji, Takamitsu Kajisa
doaj   +1 more source