Results 131 to 140 of about 3,763,617 (312)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Design and implementation of gas disaster early-warning system based on hot-standby

Gong-kuang zidonghua, 2013
In view of problem of single-point failure in hardware and software running environment of gas disaster early-warning system of coal mine, a gas disaster early-warning system based on hot-standby was proposed, and its hot-standby solution, hardware and ...
LI Ming-jian, DIAO Yong, ZHANG Yi
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Effect of General Anesthesia on Capillary Refill Time in Patients with Congestive Heart Failure Compared to the Control Group

مجله دانشکده پزشکی اصفهان, 2016
Background: Capillary refill time (CRT) largely used as a quick way to assess the cardiovascular system and the status of peripheral blood flow and perfusion in patients. On the other hand, cardiac heart failure is a complex clinical syndrome happens due
Mohammad Golparvar, Saeid Abbasi, Roya Kasiri   +2 more
doaj  

MAINTENANCE DOOZER BATUBARA MENGGUNAKAN METODE MEAN TIME BETWEEN FAILURE (MTBF) DI PT. XXXXXXX

Perwira Journal of Science & Engineering
Mean Time Between  Failure  (MTBF) merupakan rata rata waktu pada sebuah peralatan untuk dapat dioperasikan sebelum terjadinya kerusakan. Tujuan dari jurnal ini yaitu analisis maintenance Doozer batubara menggunakan metode Mean Time Between Failure (MTBF). Hasil didapatkan dari Data yang digunakan dalam laporan kerja praktik bersumber dari laporan data
Robertus Nicko, Aufa Azfa Wahyu, Muhammad Irgi Bachtiar, Budi Prasetiyo, Ahmad Mukhlisin, Muhammad Hasbi Pratama, Fajar Paundra   +6 more
openaire   +1 more source

Analisis Performansi Perawatan pada Mesin Bending Komatsu PT. Metaplas Citra Cemerlang [PDF]

, 2016
PT Metaplas Citra Cemerlang is a company that produces electrical panels and provides metal processing services. Maintaining the quality of products produced by knowing and understanding in detail the problems faced in the production process.
Astridenia, A. M. (Agvirillia), Suliantoro, H. (Hery)   +1 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Paper 12: Risk Factors and Failure Rates for Ramp Repair with ACL Reconstruction: An Analysis of 1037 Patients with a Mean Follow-up of 72 Months from the SANTI Study Group

Orthopaedic Journal of Sports Medicine
Objectives: The primary objective of this study was to determine the failure rate (defined by secondary meniscectomy) of ramp repairs performed at the time of anterior cruciate ligament reconstruction (ACLR).
Adnan Saithna MD, Charles Pioger, Merwane Ayata, Francesco Pettinari, Ahmad Abed Ali, Ali Alayne, Joao Campos, Thais Dutra Vieira, Bertrand Sonnery-Cottet MD, PhD   +8 more
doaj   +1 more source

Process characteristics and design methods for a 300 deg quad OP amp [PDF]

The results of process characterization, circuit design, and reliability studies for the development of a quad OP amplifier intended for use up to 300 C are presented.
Beasom, J. D., Patterson, R. B., III
core   +1 more source