Results 101 to 110 of about 901,213 (331)

Analysis of offshore wind turbine operation & maintenance using a novel time domain meteo-ocean modeling approach [PDF]

open access: yes, 2012
This paper presents a novel approach to repair modeling using a time domain Auto-Regressive model to represent meteo-ocean site conditions. The short term hourly correlations, medium term access windows of periods up to days and the annual distibution of
Dinwoodie, Iain Allan   +2 more
core  

Robustness of power systems under a democratic fiber bundle-like model

open access: yes, 2015
We consider a power system with $N$ transmission lines whose initial loads (i.e., power flows) $L_1, \ldots, L_N$ are independent and identically distributed with $P_L(x)$.
Yağan, Osman
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Analysis of the Reliability of the "Alternator- Alternator Belt" System

open access: yesPromet (Zagreb), 2012
Before starting and also during the exploitation of va1ioussystems, it is vety imp011ant to know how the system and itsparts will behave during operation regarding breakdowns, i.e.failures.
Ivan Mavrin   +2 more
doaj   +1 more source

Rapid Recovery for Systems with Scarce Faults

open access: yes, 2012
Our goal is to achieve a high degree of fault tolerance through the control of a safety critical systems. This reduces to solving a game between a malicious environment that injects failures and a controller who tries to establish a correct behavior.
Huang, Chung-Hao   +3 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Assessment of reliability parameters of power supply systems' schemes of industrial facilities of electrical complexes when changing the load power and area of the facility while performing technical and economic calculations

open access: yesVestnik MGTU
The relevance of the study lies in the assessment of the reliability parameters and economic efficiency of intra-shop power supply systems of enterprises with 10/0.4 kV transformer substations. The study analyzes the reliability indicators for intra-shop
Petrova R. M.   +2 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

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