Results 111 to 120 of about 872,404 (333)

Methodology for Studying the Reliability of Interlocking Devices in Bulgarian Railways

open access: yesApplied Sciences
Railway signalling systems must ensure the safe movement of trains and the reliability of the operation of their components is of utmost importance.
Emiliya Dimitrova, Vasil Dimitrov
doaj   +1 more source

Mathematical Modeling and Examination of the Effects of Structural Redundancy in а Class of Computer-Based Fault Tolerant Systems

open access: yesCybernetics and Information Technologies, 2016
The present article models and examines k˅n systems, in particular Triple modular redundancy (2˅3) and 3˅5. The aim of the study is to derive mathematical models, which are used for determining the impact of structural redundancy (the number of channels ...
Hristova Mariya
doaj   +1 more source

Analysis of offshore wind turbine operation & maintenance using a novel time domain meteo-ocean modeling approach [PDF]

open access: yes, 2012
This paper presents a novel approach to repair modeling using a time domain Auto-Regressive model to represent meteo-ocean site conditions. The short term hourly correlations, medium term access windows of periods up to days and the annual distibution of
Dinwoodie, Iain Allan   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Robustness of power systems under a democratic fiber bundle-like model

open access: yes, 2015
We consider a power system with $N$ transmission lines whose initial loads (i.e., power flows) $L_1, \ldots, L_N$ are independent and identically distributed with $P_L(x)$.
Yağan, Osman
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

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