Results 151 to 160 of about 901,213 (331)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

On designing dependable services with diverse off-the-shelf SQL servers [PDF]

, 2004
A. Avizienis, A. Avizienis, A. Vaysburd, B. Kemme, C. Babbage, D. Powell, F. Pedone, F. Schneider, I. Gashi, J. Gray, J. Gray, J.C. Laprie, M. Patino-Martinez, M. Weismann, P. Popov, P.A. Bernstein, P.E. Ammann, P.J. Traverse, P.M. Chen, R. Jimenez-Peris, R. Jimenez-Peris, S. Chandra, S. Chandra, S. Poledna, S. Poledna, T. Anderson   +25 more
core   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Design and implementation of gas disaster early-warning system based on hot-standby

Gong-kuang zidonghua, 2013
In view of problem of single-point failure in hardware and software running environment of gas disaster early-warning system of coal mine, a gas disaster early-warning system based on hot-standby was proposed, and its hot-standby solution, hardware and ...
LI Ming-jian, DIAO Yong, ZHANG Yi
doaj  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

THE EVOLUTION OF RESIDIAL RESOURCE OF THE MAIN BUILDING R-1 OF "VOLTAYR-PROM" AS A COMPLEX STRUCTURE

Structural Mechanics of Engineering Constructions and Buildings, 2016
In this paper, we have proposed a method for determining the law of variation of the resource and the prediction of the service life of the existing buildings, we have modeled the diagram of the main supporting structures of the coating in the form of a ...
K N Suhina, V A Pshenichkinа
doaj  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Bayesian estimation of the mean time between failures of subsystems with different causes using interval‐censored system maintenance data [PDF]

David Han, James Brownlow, Jesse Thompson, R. Brooks   +3 more
openalex   +1 more source