Results 61 to 70 of about 904,656 (296)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Turning Privacy Constraints into Syslog Analysis Advantage [PDF]

, 2016
Nowadays, failures in high performance computers (HPC) became the norm rather than the exception [10]. In the near future, the mean time between failures (MTBF) of HPC systems is expected to be too short, and that current failure recovery mechanisms e.g.,
Ciorba, Florina M., Ghiasvand, Siavash, Nagel, Wolfgang E.   +2 more
core  

Validation of Ultrahigh Dependability for Software-Based Systems [PDF]

, 1993
Modern society depends on computers for a number of critical tasks in which failure can have very high costs. As a consequence, high levels of dependability (reliability, safety, etc.) are required from such computers, including their software.
Barwise J, Bev Littlewood, Bishop P.G., de Groot M.H., Giloth F.K., Knight J.C., Lorenzo Strigini, Miller D.R., Perrow C., Powell D., RTCA Committee SC-176, Software Considerations in   +10 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Статистичний аналіз причин виходів з ладу гідромеханічних трансмісій кар’єрних самоскидів вантажопідйомністю 30-45 т [PDF]

, 2013
На основі статистичних даних встановлені числові показники основних причин виходу з ладу карданних валів, гідромеханічної передачі та заднього ведучого мосту гідромеханічних трансмісій кар’єрних автосамоскидів вантажопідйомністю 30 та 40-45 т виробництва
Гальченко, А. В., Монастирський, Ю. А.   +1 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Update Equipment Critically Rating Dan Analisa Kestabilan Maintenance Equipment Kategori A Dengan Nilai Mean Time Between Failures Di Pabrik PA1 B0102 PT Petrokimia Gresik

Otopro, 2018
Hasil update ECR (Equipment Critically Rating) pada pabrik PA1 functional location B0102 ditemukan beberapa equipment yang sudah tidak digunakan, beberapa equipment turun tingkat krtitisnya dibandingkan dengan sebelumnya, hal ini dikarenakan perbedaan ...
Arnes Setya Prayogo, R. Fairuz Zamani
doaj   +1 more source

Improving Mean Time Between Pump Failures [PDF]

, 2018
Discussion GroupMechanical/Metallurgical design requirements for pump components Design and installation for pump baseplates Proper hydraulic fit of pumps Mechanical alignment targets/procedures Pump repair ...
Bruck, Morg, Burton, Aaron, DePaolis, David, Litton, Bill   +3 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Statistical approach for insulation coordination of high voltage substation exposed to lightning strikes

Electrical engineering & Electromechanics
Introduction. Insulation coordination requires accurate prediction of overvoltages at various points within a substation. Computer simulations of electromagnetic transients in real structures of substations become more precise due to the improvements of ...
S. Bedoui, A. Bayadi
doaj   +1 more source