Results 71 to 80 of about 904,656 (296)

Efficient estimation of the mean time between failures in non-regenerative dependability models [PDF]

Proceedings of the 25th conference on Winter simulation - WSC '93, 1993
In this paper we discuss fast simulation techniques for estimating the steady-state mean time between failures (MTBF) in non-Markovian models of highly dependable systems. The key is to use a ratio representation of the MTBF, in which the denominator is closely related to the probability of a rare event and is therefore amenable to estimation using ...
Glynn, P.W., Heidelberger, P., Nicola, Victor F., Shahabuddin, P.   +3 more
openaire   +2 more sources

Short-term synaptic plasticity regulates the level of olivocochlear inhibition to auditory hair cells [PDF]

, 2011
In the mammalian inner ear, the gain control of auditory inputs is exerted by medial olivocochlear (MOC) neurons that innervate cochlear outer hair cells (OHCs).
Ballestero, Jimena Andrea, Elgoyhen, Ana Belen, Fuchs, Paul A., Goutman, Juan Diego, Katz, Eleonora, Zorrilla de San Martín, Javier   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Enhancing Reliability Indices in Power Distribution Grids Through the Optimal Placement of Redundant Lines Using a Teaching–Learning-Based Optimization Approach

Energies
Given the pressing need to strengthen operational reliability in electrical distribution networks, this study proposes an optimization methodology based on the Teaching–Learning-Based Optimization (TLBO) algorithm for the strategic location of redundant ...
Johao Jiménez, Diego Carrión, Manuel Jaramillo   +2 more
doaj   +1 more source

Instant restore after a media failure

, 2017
Media failures usually leave database systems unavailable for several hours until recovery is complete, especially in applications with large devices and high transaction volume.
C Mohan, C Mohan, E Levy, G Graefe, G Graefe, J Gray, JN Gray, PM Chen, T Härder   +8 more
core   +1 more source

Convergence Rate Analysis of Distributed Gossip (Linear Parameter) Estimation: Fundamental Limits and Tradeoffs [PDF]

, 2010
The paper considers gossip distributed estimation of a (static) distributed random field (a.k.a., large scale unknown parameter vector) observed by sparsely interconnected sensors, each of which only observes a small fraction of the field.
Kar, Soummya, Moura, Jose' M. F.
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Research on the intelligent control system for lithium-ion aluminium shell power battery module stacking

Mechanics & Industry
During the stacking and welding process of lithium-ion aluminium shell power battery modules, the accumulation of cell size errors can easily cause the module length to exceed the tolerance range, affecting the module length qualification rate and the ...
Sheng Qingshan, Sirikham Adisorn, Konpang Jessada, Wu Heng   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Analysis of the reasons for low mean time between failures of pumping equipment at a high-viscosity permo-carbon oil deposit

Наука. Инновации. Технологии
Sucker-rod pumping unit in operation after huff and puff cyclic steam injection operates in a wide range of rheological properties of fluids and medium temperatures.
D. A. Ivanov
doaj   +1 more source