Results 111 to 120 of about 3,844,361 (299)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

On the estimation of the mean time to failure by simulation

2017 Winter Simulation Conference (WSC), 2017
The mean time to failure (MTTF) of a stochastic system is often estimated by simulation. One natural estimator, which we call the direct estimator, simply averages independent and identically distributed copies of simulated times to failure. When the system is regenerative, an alternative approach is based on a ratio representation of the MTTF.
Glynn, Peter, Nakayama, Marvin, Tuffin, Bruno   +2 more
openaire   +3 more sources

Bayesian inference for fault based software reliability models given software metrics data [PDF]

, 2002
We wish to predict the number of faults N and the time to next failure of a piece of software. Software metrics data are used to estimate the prior mean of N via a Poisson regression model. Given failure time data and a some well known fault based models
Rodríguez Bernal, María Teresa, Wiper, Michael Peter   +1 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Review of fault detection, localization and tolerant in multilevel inverter

Energy Reports
Multilevel inverters (MLIs) find a wide range of applications in high and medium-power applications, including electric vehicles, FACTS devices, HVDC, and renewable energy systems. Since it utilizes a large number of semiconductor devices and capacitors,
Hillol Phukan, Avadh Pati, Jiwanjot Singh, Nicu Bizon   +3 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Reliability and Availability Analysis of k-out-of-M+S Retrial Machine Repair System with Two-Way Communication

Mathematics
This paper studies the reliability and availability of a k-out-of-(M+S) retrial machine repair system with two-way communication, consisting of M primary components and S warm standby components.
Chen-Hsiang Hsieh, Tzu-Hsin Liu, Fu-Min Chang, Yu-Tang Lee   +3 more
doaj   +1 more source

Supraspinal Fatigue Is Similar in Men and Women for a Low-Force Fatiguing Contraction [PDF]

, 2011
Purpose: This study determined the contribution of supraspinal fatigue to the sex difference in neuromuscular fatigue for a low-intensity fatiguing contraction.
Harkins, April, Hunter, Sandra K., Keller, Manda L., Pruse, Jaclyn, Schlinder-Delap, Bonnie, Yoon, Tejin   +5 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Temperature-Driven Reliability Analysis of Power Grid Failures: A Weibull Distribution Approach To Outage Prediction and Mitigation

Journal of Statistical Theory and Applications (JSTA)
This study aims to elucidate the critical relationship between temperature variations and power outages. We propose to employ the Weibull distribution, a fundamental tool in reliability analysis, to assess the impact of temperature on power grid failures
Simon Ahumah Ocansey, Marwan Bikdash
doaj   +1 more source