Results 91 to 100 of about 3,844,361 (299)
Defender: A Low Overhead and Efficient Fault-Tolerant Mechanism for Reliable on-Chip Router
IEEE Access, 2019 The ever-shrinking size of a transistor has made Network on Chip (NoC) susceptible to faults. A single error in the NoC can disrupt the entire communication.
Naveed Khan Baloch +2 more
doaj +1 more source
Life analysis of restored and refurbished bearings [PDF]
An analysis of the potential life of refurbished and restored bearings was performed. The sensitivity of 10-percent life and mean-time-between-failure to the effects of cumulative fatigue damage and the amount of stressed volume removed in the ...
Cowgill, G. R. +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
IMPLEMENTASI PREVENTIVE DAN AUTONOMOUS MAINTENANCE DI PT. INTI ABADI KEMASINDO [PDF]
, 2008 IMPLEMENTASI PREVENTIVE DAN AUTONOMOUS MAINTENANCE DI PT. INTI ABADI KEMASINDO - Synchronous dan random servicing, downtime, preventive maintenance, reliability, total expected cost, mean time to failure, mean time to ...
BUDI MULYONO, SUKARTONO
core
Time Delay in Swiss Cheese Gravitational Lensing
, 2010 We compute time delays for gravitational lensing in a flat LambdaCDM Swiss cheese universe. We assume a primary and secondary pair of light rays are deflected by a single point mass condensation described by a Kottler metric (Schwarzschild with Lambda ...
Chen, Bin, Dai, Xinyu, Kantowski, Ronald
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Real-time failure control (SAFD) [PDF]
The Real Time Failure Control program involves development of a failure detection algorithm, referred as System for Failure and Anomaly Detection (SAFD), for the Space Shuttle Main Engine (SSME).
Eckerling, Sherry J. +2 more
core +1 more source