Results 81 to 90 of about 89,725,173 (290)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Probabilistic Approach for Threshold Reliability Structures with Three Different Types of Components

Mathematics
In the present work, we study threshold reliability systems consisting of three different kinds of independent components. Within these structures, the components belonging to the same type, share a common reliability and the same weight. The reliability
Ioannis S. Triantafyllou
doaj   +1 more source

Neutrosophic Reliability Assessment of Hydroelectric Power Plant using Universal Generating Function Technique [PDF]

Neutrosophic Sets and Systems
The main objective of present study is to assess the reliability measures of a hydroelectric power plant under neutrosophic environment. There are several reliability evaluations like Markovian approach, Semi-Markovian approach, etc.
Kanak Saini, Monika Saini, Ashish Kumar , Dinesh Kumar Saini   +3 more
doaj   +1 more source

Efficiency in Estimation of Mean Time to Failure in a Two-Parameter Exponential Failure Model [PDF]

, 1977
When comparing two point estimators of some parametric function, Pitman-closeness efficiency gives the odds in favor of one of the estimators being closer to the true value than is the other in a given situation.
Dyer, Danny D.
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Optimization of Socks Production in South African Knitting Plant: A Cost-Effective Alternative to Industry 4.0

Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri
The textile industry, particularly sock manufacturing, faces increasing demands for productivity and cost efficiency amid global competition. This study presents a comprehensive case study on optimizing sock production in a South African knitting plant ...
Kemlall Ramdass, Isaac Olalere
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Defender: A Low Overhead and Efficient Fault-Tolerant Mechanism for Reliable on-Chip Router

IEEE Access, 2019
The ever-shrinking size of a transistor has made Network on Chip (NoC) susceptible to faults. A single error in the NoC can disrupt the entire communication.
Naveed Khan Baloch, Muhammad Iram Baig, Masoud Daneshtalab   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source