Results 61 to 70 of about 1,446,763 (330)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Zanco Journal of Humanity SciencesIn this research two identical parallel electric generators with repair a failed one have been analyzed stochastically by two methods, first by method based on certain probability assumptions and second through three state Markov chain, classified as ...
Bestun Merza Abdulkareem
doaj +1 more source
Profit Analysis of Two-Dissimilar-Unit Cold Standby System with Three States under Human Failure [PDF]
The Egyptian Statistical Journal, 2011 This paper deals with the Mean Time to System Failure (MTSF), steady-state availability and profit analysis of a two-dissimilar-unit cold standby system with considering human failure.
M.Yas Haggag, Ahmed Khayar
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Delayed failure of software components using stochastic testing [PDF]
, 2012 The present research investigates the delayed failure of software components and addresses the problem that the conventional approach to software testing is unlikely to reveal this type of failure. Delayed failure is defined as a failure that occurs some
Gardiner, Jeremy
core
Journal of Engineering and Management in Industrial System, 2017 PT. XYZ is one of many paper manufacturing companies in East Java which produces Exercise Book. The company implements corrective engine maintenance system where new components replacement is done when the engine is damaged.
Fina Andika Frida Astuti +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Mean time to failure of hydraulic brake valve
, 2020 V današnjem času se daje velik poudarek varnosti in zanesljivosti naprav. Eden izmed novejših standardov glede varnosti strojev in naprav je SIST EN ISO 13849-1.
Novak, Nejc
core
HeliyonObjective: To analyse and continually improve existing issues in the quality improvement process of medical linear accelerators (LINACs) and enhance the quality control management of LINACs.
Qi-Peng Lu +8 more
doaj +1 more source