Results 71 to 80 of about 3,844,361 (299)

STRATEGIES OF MAINTENANCE MODEL FOR EXERCISE BOOK MANUFACTURING MACHINE ON PAPER INDUSTRY BY IMPLEMENTING MONTE CARLO SIMULATION APPROACH

Journal of Engineering and Management in Industrial System, 2017
PT. XYZ is one of many paper manufacturing companies in East Java which produces Exercise Book. The company implements corrective engine maintenance system where new components replacement is done when the engine is damaged.
Fina Andika Frida Astuti, Sugiono Sugiono, Moch Agus Choiron   +2 more
doaj   +1 more source

Simulated Dynamical Weakening and Abelian Avalanches in Mean-Field Driven Threshold Models

, 2004
Mean-field coupled lattice maps are used to approximate the physics of driven threshold systems with long range interactions. However, they are incapable of modeling specific features of the dynamic instability responsible for generating avalanches. Here
Andersen, Burridge, Dahmen, Dhar, Dhar, Ding, Durbin, Eric F. Preston, Ertas, Ferguson, Fisher, Giamarchi, John Rundle, Jorge S. Sá Martins, Lerche, Nakanishi, Preston, Rundle   +17 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Challenging the Mean Time to Failure: Measuring Dependability as a Mean Failure Cost

2009 42nd Hawaii International Conference on System Sciences, 2009
As a measure of system reliability, the mean time to failure falls short on many fronts: it ignores the variance in stakes among stakeholders; it fails to recognize the structure of complex specifications as the aggregate of overlapping requirements; it fails to recognize that different components of the specification carry different stakes, even for ...
openaire   +1 more source

Assessment of potential cardiotoxic side effects of mitoxantrone in patients with multiple sclerosis [PDF]

, 2005
Previous studies showed that mitoxantrone can reduce disability progression in patients with multiple sclerosis (MS). There is, however, concern that it may cause irreversible cardiomyopathy with reduced left ventricular (LV) ejection fraction (EF) and ...
Ariane Groβ, Athanasiou T, Avasarala JR, De Castro S, Dukart G, Edan G, Edan G, Foster BJ, Ghalie RG, Goffette S, Gonsette RE, Gonsette RE, Goodin DS, Hartung HP, Herman EH, Kappos L, Klaus Jahn, Koch CG, Kronik G, Kurtzke JF, Mather FJ, Mauch E, Michael Näbauer, Michael Strupp, Millefiorini E, Noseworthy JH, Posner LE, Reinhard Hohlfeld, Ruel M, Strotmann JM, Teichholz LE, Thomas Brandt, Vera Carina Zingler, Voltz R, Yudkin PL, Zephir H, Zingler VC   +36 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Continuous quality improvement project to reduce the downtime of medical linear accelerators: A case study at Zhejiang Cancer Hospital

Heliyon
Objective: To analyse and continually improve existing issues in the quality improvement process of medical linear accelerators (LINACs) and enhance the quality control management of LINACs.
Qi-Peng Lu, Yong Wu, Xiao-Dong Mao, Hua-Jun Wan, Jian Shao, Qi-Kai Yu, Wei Zhang, Yue Zhao, Ci-Yong Wang   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

On a method for mending time to failure distributions [PDF]

Many software reliability growth models assume that the time to next failure may be infinite; i.e., there is a chance that no failure will occur at all. For most software products this is too good to be true even after the testing phase.
Grottke, Michael, Trivedi, Kishor S.
core