Results 241 to 250 of about 1,338,716 (305)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Risk assessment of holmium laser induced ureteral stricture: <i>in-vivo</i> experiments using a pig model. [PDF]

PeerJ
He Q, Huang Q, Qi Q, Xu Y, Hou B, Hao Z.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Application of cephalad approach laparoscopic transabdominal preperitoneal mesh repair in mid-lower abdominal incisional hernias. [PDF]

BMC Surg
Wang H, Wang S, Pan C, Ni X, Zhang C, Li B, Yu J.   +6 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Gap Formation and Fixation Strength After Unicortical Quadriceps Tendon Repair with All-Suture Anchors. [PDF]

Orthop J Sports Med
Werner BC, Tejada MD, Wittstein JR, Frank RM, Evans MK, Khoury AN, Smith BL.   +6 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Attention to the Editor - Case series: "Laparoscopic robot-assisted extravesical repair of vesicovaginal fistula post-hysterectomy: a study of peritoneal flap inlay technique and outcomes". [PDF]

J Robot Surg
Breu B, Schregel C, Förster B, Padevit C, John H.   +4 more
europepmc   +1 more source

Response strategies of Ochroma lagopus to short-term low-temperature stress and rewarming: a photosynthesis-antioxidant-carbon network analysis. [PDF]

Front Plant Sci
Liu Y, Zhu W, Du G, Chen J, Wu J, Shi R.
europepmc   +1 more source

Percutaneous closure of ventricular septal rupture after myocardial infarction: a case report of competing timelines in multifactorial shock. [PDF]

Eur Heart J Case Rep
Cook TA, Schumaecker SK, Patibandla A, Valle NJ, Summers MR.   +4 more
europepmc   +1 more source