Cell aging preserves cellular immortality in the presence of lethal levels of damage. [PDF]
, 2019 Cellular aging, a progressive functional decline driven by damage accumulation, often culminates in the mortality of a cell lineage. Certain lineages, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells.
Chao, Lin +4 more
core +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Comparative analysis of Desarda and Lichtenstein Inguinal Hernia Repair Techniques
Journal of Shalamar Medical & Dental CollegeBackground: Inguinal hernia repair is the most commonly done procedure on the surgical floor these days. Objective: The study aims to evaluate and compare two different inguinal hernia repair techniques in terms of preoperative and postoperative ...
Muhammad Hamza Rana +5 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
PENJADWALAN PRODUKSI DENGAN PENDEKATAN THEORY OF CONSTRAINT UNTUK MENGURANGI BOTTLENECK (Studi Kasus: PT Jati Mas Indonesia Singosari-Malang) [PDF]
, 2008 PT Jati Mas Indonesia is peripatetic company is industrial area of furniture owning characteristic of Job Shop. In this time problem faced by company is level of Work In Process (WIP) the highness, caused by time processed the very old the station and ...
FAUZIYAH, ANNIKMATUL
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin [PDF]
, 2014 Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs).
Alex D. Herbert +36 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Production, 2017 The time interval between inspections of cold standby systems is a crucial decision to ensure the appropriated system reliability and the lowest costs possible.
Angélica Alebrant Mendes +1 more
doaj +1 more source
Effect of linear energy transfer (LET) on complexity of alpha-particle-induced chromosome aberrations in human CD34+ cells. [PDF]
, 2007 The aim of this study was to assess the relative influence of linear energy transfer (LET) of α-particles on chromosome aberration complexity in the absence of significant other track structure differences.
Anderson, RM +5 more
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