Results 91 to 100 of about 1,338,716 (305)

PARP-3 and APLF function together to accelerate nonhomologous end joining [PDF]

, 2010
PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function. We show that PARP-3 is stimulated by DNA double-strand breaks (DSBs) in vitro and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate
Ahel, Ame, Anna E.O. Fisher, Audebert, Bekker-Jensen, Benjamin, Bernardo Reina-San-Martin, Boulton, Brown, Bryant, Bryant, Caldecott, Caldecott, Critchlow, Ding, Drouet, El-Khamisy, Farmer, Fisher, Grawunder, Guy Poirier, Hochegger, Hottiger, Iles, Isabelle Robert, Kanno, Keith W. Caldecott, Kickhoefer, Kleine, Le Page, Lehtio, Limei Ju, Lobrich, Loseva, Macrae, Mahaney, Maria C. Zuma, Mehrotra, Michele Rouleau, Morrison, Okano, Otto, Poirier, Robert, Roberts, Rogakou, Rogakou, Rouleau, Rulten, Smith, Soulas-Sprauel, Stevnsner, Stuart L. Rulten, Sugimura, Trucco, Wang, Yan, Yang, Yano, Yano   +59 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent Anterior Glenohumeral Instability-Arthroscopic Results of Bankart Repair

Orthopaedic Journal of Sports Medicine, 2014
Objectives: In the treatment of traumatic anterior shoulder instability there is still not formed a ideal consensus. Although the results of the open technique for repairing Bankart lesions detected in these patients, in recent years with the development
Ahmet Guney, İbrahim Karaman, Murat Kahraman, Mithat Öner, Erdal Uzun, Ökkeş Bilal   +5 more
doaj   +1 more source

Reduce mean time to repair of mining equipment with lean six sigma

Operations Excellence: Journal of Applied Industrial Engineering
As the size and complexity of mining equipment grow, the impact of equipment failure becomes increasingly critical, often leading to costly downtime and production delays. Mining equipment performance depends on several factors, including equipment reliability, the operating environment, maintenance efficiency, operating processes, and the technical ...
Selamat W. Hia, Prasetyo Adji Dian Pramudjito   +1 more
openaire   +1 more source

Availability and mean time between failures of redundant systems with random maintenance of subsystems [PDF]

It is shown how the availability and MTBF (Mean Time Between Failures) of a redundant system with subsystems maintenanced at the points of so-called stationary renewal processes can be determined from the distributions of the intervals between ...
Schneeweiss, W.
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Penentuan Kinerja Sistem SCADA PT.PLN (Persero) Unit Pelaksana Pengatur Beban Area Jakarta dan Banten Berdasarkan Nilai Mean Time To Repair

Prosiding Seminar Nasional Teknoka, 2020
Sistem SCADA dan Telekomunikasi yang dibentuk dari sub sistem teleinformasi data yang merupakan rangkaian perangkat dan dapat menghasilkan fungsi power sistem untuk dikontrololeh sub sistem master station pada yang terdapat pada kontrol center. Dalam menjalankan fungsinya setiap peralatan pada masing – masing sub sistem harus dapat memberikan layanyan ...
Dewi Astuti, Kun Fayakun, Harry Ramza
openaire   +2 more sources

Relationship Between Quantitative MRI Biomarkers and Patient-Reported Outcome Measures After Cartilage Repair Surgery: A Systematic Review. [PDF]

, 2018
Background:Treatment of articular cartilage injuries remains a clinical challenge, and the optimal tools to monitor and predict clinical outcomes are unclear.
Cole, Brian J, Cotter, Eric, Davey, Annabelle, Lansdown, Drew A, Wang, Kevin   +4 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Analysis of offshore wind turbine operation & maintenance using a novel time domain meteo-ocean modeling approach [PDF]

, 2012
This paper presents a novel approach to repair modeling using a time domain Auto-Regressive model to represent meteo-ocean site conditions. The short term hourly correlations, medium term access windows of periods up to days and the annual distibution of
Dinwoodie, Iain Allan, McMillan, David, Quail, Francis   +2 more
core