Results 101 to 110 of about 1,338,716 (305)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Comparative Analysis Between Laparoscopic Extravesical Repair and Laparoscopic O’Connor Repair for Supratrigonal Vesicovaginal Fistula

Urology Research and Practice
Objective: The objective of the study was to conduct a comparative analysis of various intraoperative parameters and postoperative outcomes between the laparoscopic extravesical repair versus the laparoscopic O’Connor repair techniques in management of ...
Yash Manharlal Tilala, Sabyasachi Panda, Amiya Shankar Paul, Pramod Kumar Mohanty, Sanjay Choudhuri, Samir Swain   +5 more
doaj   +1 more source

Space Transportation System Availability Relationships to Life Cycle Cost [PDF]

, 2009
Future space transportation architectures and designs must be affordable. Consequently, their Life Cycle Cost (LCC) must be controlled. For the LCC to be controlled, it is necessary to identify all the requirements and elements of the architecture at the
Chen, Timothy T., Donahue, Benjamin B., Rhodes, Russel E.   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Duration of Surgery and Learning Curve Affect Rotator Cuff Repair Retear Rates: A Post Hoc Analysis of 1600 Cases

Orthopaedic Journal of Sports Medicine, 2020
Background: Arthroscopic rotator cuff repair can be quite complex and time consuming, particularly early in the surgeon’s learning curve. Hypothesis: Patients who have undergone rotator cuff repair with shorter operative times will be less likely to have
Ashleigh R. Elkins MD, Patrick H. Lam MD, PhD, George A.C. Murrell MD, DPhil   +2 more
doaj   +1 more source

Penentuan Jadwal Preventive Maintenance Mesin-mesin Di Stasiun Gilingan (Studi Kasus Pg. Lestari Kertosono) [PDF]

, 2015
Kebutuhan gula semakin meningkat seiring dengan peningkatan jumlah penduduk dan peningkatan pendapatan masyarakat, Untuk memproduksi gula dalam jumlah yang banyak, diperlukan suatu alat yang dapat membantu dan mempercepat proses produksi tersebut yakni ...
Revitasari, C. (Cindy), Novareza, O. (Oyong), Darmawan, Z. (Zefry)   +2 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Reliability Mathematical Models of Repairable Systems With Uncertain Lifetimes and Repair Times

IEEE Access, 2018
In system reliability problems, the lifetimes and the repair times are usually indeterministic. When insufficient samples are available to estimate distribution functions of the lifetimes and the repair times, it is rational to invite some experts to ...
Ying Liu, Yao Ma, Zhigang Qu, Xiaozhong Li   +3 more
doaj   +1 more source

Availability analysis of the traveling-wave maser amplifiers in the deep space network. Part 1: The 70-meter antennas [PDF]

The results of the reliability and availability analyses of the individual S- and X-band traveling-wave maser (TWM) assemblies and their operational configurations in the 70-meter antennas of NASA's Deep Space Network (DSN) are described.
Issa, T. N.
core   +1 more source

Effect of sample age on the self-healing properties of cementitious mateials with superabsorbent polymers [PDF]

, 2016
To obtain sustainable construction materials, occurring cracks in concrete should be repaired. However, as this often manual repair is time-consuming and expensive, self-healing may provide a solution.
De Belie, Nele, Snoeck, Didier
core