Results 121 to 130 of about 88,764,951 (299)

Short-Term Outcome of Tetralogy of Fallot Repair: A Single Center Experience    in A Developing Country

Pakistan Armed Forces Medical Journal
Objective: To note short-term outcome of patients undergoing tetralogy of fallot repair. Study Design: Retrospective longitudinal study. Place and Duration of Study: Department of Pediatric Cardiology, National Institute of Cardiovascular Disease ...
Aliya Kemal Ahsan, Rumana Sangi, Abdul Sattar Shaikh, Rajab Ali Khokhar, Mujeeb ur Rehman, Sohail Khan Bangash, Saad Bader Zaki, Najma Patel   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Under the Clouds of War

, 1972
Consists of film clips of World War II events, including Mussolini\u27s invasion of Ethiopia and Hitler\u27s march into Austria.
Time-Life Video
core  

The Anterior Preperitoneal Approach for Repair of Complex Inguinal Hernias

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014
Purpose: The gold standard for the repair of inguinal hernias is the Lichtenstein repair. However, complex inguinal hernias such as recurrent hernias, giant hernias, femoral hernias or combined hernias are present, it is necessary to choose different ...
Safa Onel, Faruk Karateke, Sefa Ozyazici, Ebru Menekse, Adnan Kuvvetli, Mehmet Ozdogan   +5 more
doaj  

Tragus Perichondrium–Cartilage Island and Temporalis Muscle Fascia for Repairing Tympanic Membrane Perforation Under the Otoendoscope: A Randomized Controlled Trial

Ear, Nose & Throat Journal
Objective To compare the clinical effects of repairing tympanic membrane perforation (TMP) with the tragus perichondrium–cartilage island and temporalis muscle fascia (TMF) under the otoendoscope.
Yu-Qiang Hu MM, Ming-Zhen Zou MM, Hai Sun MM, Mei Ma MM, Jun An MM, Ran Chen BM, Liang-Jun Cheng MM, Bing Liu MM   +7 more
doaj   +1 more source

Analysis of Preventive Maintenance on Forklifts and Reach Trucks by Calculating Mean Time Between Failure and Mean Time to Repair at PT. DSV Solutions Indonesia

Proceeding of International Conference on Science and Technology UISU
The aim of this research is to analyze preventive maintenance for material handling equipment, specifically Forklifts and reach trucks, at PT. DSV Solutions Indonesia over a one-year period (January-December 2023). The analysis employs the Mean Time Between Failure (MTBF), Mean Time To Repair (MTTR), and Availability methods.
Wirda Novarika, Mahrani Arfah, Rizal Abdul Khoir   +2 more
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source