Results 121 to 130 of about 1,338,716 (305)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A systematic review of infected descending thoracic aortic grafts and endografts

, 2019
Objective: The objective of this study was to collect and critically analyze the current evidence on the modalities and results of treatment of descending thoracic aortic surgical graft (SG) and endograft (EG) infection, which represents a rare but ...
Chakfe, Nabil, Chiesa, Roberto, Grandi, Alessandro, Kahlberg, Andrea, Loschi, Diletta, Melissano, Germano, Moreels, Nathalie, Vermassen, Frank   +7 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Revision Meniscal Repair - Failure rates, clinical outcome and patient satisfaction

Orthopaedic Journal of Sports Medicine, 2019
Aims and Objectives: Failure of isolated primary meniscal repair must be expected in 14% - 28%. Patients requiring revision surgery may benefit from revision meniscal repair, however, the results of revision meniscal repair remain unclear. The purpose of
Andreas Fuchs MD, Ferdinand Kloos MD, Gerrit Bode MD, Kaywan Izadpanah MD, PD, Norbert Südkamp MD, Prof., Matthias J. Feucht MD, PD   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Operative Repair of Hamstring Injuries From the Jackling Position in Rugby

Orthopaedic Journal of Sports Medicine
Background: The jackling position within rugby has not been previously described as a mechanism for proximal hamstring injuries. Hypothesis: Acute surgical repair of proximal hamstring avulsion injuries sustained from the jackling contact position ...
Joshua W. Thompson BSc(Hons), MBChB, Ricci Plastow MBBS, Babar Kayani BSc(Hons), MBBS, PhD, Peter Moriarty MBBCh, MCH, Ben Stirling BSc(Hons), MSc, Fares S. Haddad Prof., MD(Res)   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Short-Term Outcome of Tetralogy of Fallot Repair: A Single Center Experience    in A Developing Country

Pakistan Armed Forces Medical Journal
Objective: To note short-term outcome of patients undergoing tetralogy of fallot repair. Study Design: Retrospective longitudinal study. Place and Duration of Study: Department of Pediatric Cardiology, National Institute of Cardiovascular Disease ...
Aliya Kemal Ahsan, Rumana Sangi, Abdul Sattar Shaikh, Rajab Ali Khokhar, Mujeeb ur Rehman, Sohail Khan Bangash, Saad Bader Zaki, Najma Patel   +7 more
doaj   +1 more source

Reducing Mean Time to Repair (MTTR) with AIOps: An Advanced Approach to IT Operations Management

Abstract In the ever-changing world of IT operations, reducing downtime and rapidly resolving incidents are crucial and are two of the primary objectives. This paper investigates the use of artificial intelligence in IT operations (AIOps) to significantly reduce mean time to repair (MTTR).
Ruchil Shah, Nidhi H Divecha
openaire   +1 more source