Results 71 to 80 of about 2,683,293 (266)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

On the characterization of the harmonic pseudospheres via Kuran’s functions and single-layer potentials

open access: yesBruno Pini Mathematical Analysis Seminar
We present some characterizations of the harmonic pseudospheres in terms of the so called Kuran's functions and of the single-layer potentials. Our characterizations apply to solid, harmonically stable domains.
Giovanni Cupini, Ermanno Lanconelli
doaj   +1 more source

On the mean value theorem for analytic functions. [PDF]

open access: yesMichigan Mathematical Journal, 1986
The author looks for a certain analogue of the mean value theorem for analytic functions defined in the unit disk \({\mathbb{D}}\) of the complex plane \({\mathbb{C}}\). Therefore, he defines for some region \(R\subset {\mathbb{C}}\) the family B(R) of analytic functions on \({\mathbb{D}}\) with f'(\({\mathbb{D}})\subset R\), and m(R) to be the ...
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Design and analysis of herringbone gear with sixth-order transmission error based on meshing vibration optimization

open access: yesAdvances in Mechanical Engineering, 2017
To reduce the herringbone gear transmission vibration and noise, an optimization design method about the meshing vibration of herringbone gear is provided with a controllable sixth-order polynomial function of transmission error.
Feng Wang   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mean value problems of Flett type for a Volterra operator

open access: yesElectronic Journal of Differential Equations, 2013
In this note we give a generalization of a mean value problem which can be viewed as a problem related to Volterra operators. This problem can be seen as a generalization of a result concerning the zeroes of a Volterra operator in the Banach space of ...
Cezar Lupu
doaj  

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