Results 141 to 150 of about 6,190,775 (296)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Collectivism and meaning-making: A search for moderators. [PDF]

PLoS One
Oyserman D, Huang Y, Jeon AY.
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Illness Meaning-Making in an Oncology Support Group: A Longitudinal Lexical Correspondence Analysis of Group Discourse. [PDF]

Eur J Investig Health Psychol Educ
Venuleo C, Colavero P, Padova S, Carlo MSD.   +3 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Preparing for Care: A Clinician's Perspective on Anticipatory Caregiving and Meaning Making. [PDF]

J Particip Med
Modesto-Lowe V.
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Not Too Young to Understand: Meaning Making From the Perspectives of School-Aged Children With Cancer-A Scoping Review. [PDF]

Psychooncology
Wang Y, Jin C, Currin-McCulloch J, MacPhee D, Rosenberg AR, Yang Y, Su Z, Liu P, Wang J, Pryor S.   +9 more
europepmc   +1 more source

Beyond Deus Ex Machina: Multimedia Journals as Epistemic Infrastructures for Meaning-Making in Steam

Meaning-making in science education Meaning is central to science education, where learning depends on connecting conceptual knowledge, material experience, and epistemic practice. From a Deweyan perspective, knowledge that is not grounded in experience
Steinbach, Alfred, Gfeller, Frank, Buser Moser, Claudia   +2 more
core