Results 91 to 100 of about 243,984 (315)
The Impact of Volunteer Wildlife Caregiving on Meaning in Life in Mid-Aged and Older Australians
Behavioral SciencesMeaning in life is a key contributor to healthy aging, yet the mechanisms through which it is sustained remain underexplored. This study investigated the impact of volunteer wildlife caregiving on meaning in life among aging Australians, focusing on the ...
Claudia Scott, Nancy A. Pachana
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Meaning-making processes among bereaved mothers who have lost a child to cancer [PDF]
, 2007 Includes bibliographical references (leaves 86-93).The loss of a child constitutes a crisis of meaning, as prior meaning structures and fundamental assumptions about the world are shattered, and the natural order of life and death is undennined ...
Lipshitz, Marc
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Dispositional optimism and life meaning and purpose in the elderly [PDF]
, 1990 This study investigated the relationship between the constructs of Dispositional Optimism and Meaning and Purpose in Life among the elderly. These constructs emerged as germane to literature in Gerontology, Health Psychology, and Viktor Frankl\u27s ...
Guarnera, Sharon
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
How Meaning in Life Affects Goal Achievement
, 2019 Previous research has found meaning in life (i.e., a sense of life purpose; MIL) relates to many adaptive benefits such as increased mood, motivation, and goal achievement.
White, Grace
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
International Journal of Child, Youth & Family StudiesThis study aimed to investigate the correlations between the Cinderella complex — the desire in a woman sto be cared for and protected by another person, particularly a man — and each of two factors: adverse childhood experiences (ACEs) and the meaning ...
Habibe Bay Özçalık +2 more
doaj +1 more source