Results 101 to 110 of about 243,984 (315)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
DESARROLLO Y ESTRUCTURA DE LA ESCALA DIMENSIONAL DEL SENTIDO DE VIDA [PDF]
Acta Colombiana de Psicología, 2011 In recent years, the interest for identifying specific factors that may influence our health has greatly increased, especially issues like meaning of life, happiness and pursuit of goals. From the humanistic and logotherapeutic approaches, the meaning of
Martínez Ortiz , Efrén +3 more
doaj
The Meaning of Meaning; and Pleasure as Necessarily the Only Purpose of Life
Hitherto, other approaches to ethics have either been circular or have failed to provide a satisfactory grounding for what’s intrinsically desirable. This paper endeavours to ground ethics anew, not merely in facts, but in necessity. This paper introduces a novel framework of ethics, demonstrating that pleasure is necessarily the sole summum bonum and
openaire +2 more sources
Fostering Purpose in Life / Meaning in Life Across the Life Span
, 2017 This thesis addresses the idea of purpose and meaning in life and how it can be intentionally fostered across the lifespan. Purpose and meaning in life, as it relates to well-being, is considered by some scholars to be the highest-level construct from which all other lower-level constructs of well-being flow (Kashdan & McKnight, 2009).
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Development of Meaning and Purpose in Life Among Adolescents in Germany and Maine [PDF]
, 2020 The purpose of this study was to investigate the sources of meaning and purpose in life for adolescents, and to examine if and how cultural factors and the adolescent period of development might influence the sources from which meaning and purpose is ...
Ho, Janika
core +1 more source
Addicta: The Turkish Journal on AddictionsIn the present study, the intermediary role of searching for meaning in the relationship between loneliness and digital game addiction in young adults was examined.
Kübra Küçükşen, Hatice Budak
doaj +1 more source
The mediator role of attitude towards aging and elderliness in the effect of the meaning and purpose of life on death anxiety. [PDF]
Curr Psychol, 2022 Kahraman S, Erkent D.
europepmc +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source