Results 121 to 130 of about 984,374 (339)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Testing work meaning violation as a mediator between organizational dehumanization and emotional exhaustion

open access: yesScientific Reports
This study examined the mediating effect of work-meaning violation between organizational dehumanization and emotional exhaustion. Path analysis was performed with a two-wave dataset of 574 participants.
Francis Cheung
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

SENTIDO DO TRABALHO E ORIENTAÇÃO PARA O TRABALHO: UM ESTUDO EM UNIVERSIDADES PÚBLICAS DE MINAS GERAIS E DO QUEBEC

open access: yesRevista Gestão Universitária na América Latina, 2015
This study evaluates the relationship between the meaning of work and job orientation for professors of Minas Gerais and Quebec and correlate these results with Quality of Working Life.
Ana Alice Vilas Boas, Estelle M. Morin
doaj  

Letter to Your Grave. [PDF]

open access: yesFam Med, 2023
Silk H.
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Meaning: An intersemiotic perspective

open access: yes, 1995
Meaning is not well described as a merely linguistic notion. Yet in the majority of works in semantics, what someone means by doing something is strictly separated from what a linguistic expression means, what a visual sign means, what an action means ...
Ruthrof, H.
core  

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