Results 161 to 170 of about 984,374 (339)
Adaptation to Organizational Change: The Role of Meaning-making and other Psychological Resources
, 2013 The pace of organizational change has increased and multiple change-initiatives tend to overlap, therefore, organizations are in need of resourceful, adaptable employees who can handle change on an ongoing basis.
Van den Heuvel, M. +1 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Issues raised by Ruthrof’s ’Meaning: An intersemiotic perspective’
, 1997 In 'Meaning: An intersemiotic perspective', Ruthrof argues that the entirety of human experience can be construed in terms of sign systems. Following Peirce, who maintains that we think only in signs, he says: ...
King, D.
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Being Buddha at Work 108 Ancient Truths on Change, Stress, Money, and Success
Combining the talents of a professor of religion and an expert on workplace dynamics, this book continues the tradition begun by its bestselling predecessor, What Would Buddha Do (more than 30,000 copies sold), as yet another perfect tool for bringing ...
The Dalai Lama, The Dalai. +2 more
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, 2000 The thesis takes a 'first principles' approach to defining meaningful work. Although a great deal of philosophical effort has been directed at the analysis and discussion of linguistic meaning, the same is not true of other contexts in which we describe ...
Parris, Richard
core
Online Brazilian Journal of Nursing, 2007 This study aimed at understanding the meaning of the quality of life at work under the optics of the nursing team in the hospital everyday work. This is a quality research, based on the referential of phenomenology.
Vera Nilda Neumann +1 more
doaj
The Meaning of Work and Self-Management Experiences among Elderly Workers with Multiple Chronic Diseases: A Qualitative Study. [PDF]
Healthcare (Basel), 2020 Kim J, Ha J.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source