Results 201 to 210 of about 518,991 (261)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Will to Meaning: A Review of Man’s Search for Meaning

ILN Journal: Indian Literary Narratives
P.Antony Maria Jenobhar
doaj   +1 more source

The impact of physical exercise on depression among college students: the mediating role of core self-evaluation and meaning in life. [PDF]

Front Psychol
Ji X, Liu S, Ye Z, Shi H, Chen F.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The influence of social support and sentence length on meaning in life among incarcerated women in Ecuador. [PDF]

Front Psychol
Andrade LI, Viñán-Ludeña MS, Benitez J, Armijos G, Maldonado R.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Daily Meaning in Life Buffers the Within-Person Relationships Between Perceived Burdensomeness and Thwarted Belongingness With Next-Day Suicidal Ideation: An Ecological Momentary Assessment Study. [PDF]

Suicide Life Threat Behav
Cenkner DP, Duan A, Horwitz AG, Vijayakumar KSM, Odgers CL, Burgess HJ, Zalta AK.   +6 more
europepmc   +1 more source

Alexander Zholkovsky: From the Life of Meaning to the Meaning of Life [PDF]

, 2019
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

"Finding meaning in life after a cancer diagnosis": A mixed methods study with Latinos with advanced cancer. [PDF]

Palliat Support Care
Costas-Muniz R, Torres-Blasco N, Nuñez SM, Olivero Dos Santos L, Galindo-Vázquez O, Breitbart W, Castro E.   +6 more
europepmc   +1 more source